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Proteogenomic Characterization of Human Early-Onset Gastric Cancer
- Proteogenomic Characterization of Human Early-Onset Gastric Cancer
- Mun, Dong-Gi; Bhin, Jinhyuk; Kim, Sangok; Kim, Hyunwoo; Jung, Jae Hun; Jung, Yeonjoo; Jang, Ye Eun; Park, Jong Moon; Kim, Hokeun; Jung, Yeonhwa; Lee, Hangyeore; Bae, Jingi; Back, Seunghoon; Kim, Su-Jin; Kim, Jieun; Park, Heejin; Li, Honglan; Hwang, Kyu-Baek; Park, Young Soo; Yook, Jeong Hwan; Kim, Byung Sik; Kwon, Sun Young; Ryu, Seung Wan; Park, Do Youn; Jeon, Tae Yong; Kim, Dae Hwan; Lee, Jae-Hyuck; Han, Sang-Uk; Song, Kyu Sang; Park, Dongmin; Park, Jun Won; Rodriguez, Henry; Kim, Jaesang; Lee, Hookeun; Kim, Kwang Pyo; Yang, Eun Gyeong; Kim, Hark Kyun; Paek, Eunok; Lee, Sanghyuk; Lee, Sang-Won; Hwang, Daehee
- DGIST Authors
- Hwang, Daehee
- Issue Date
- Cancer Cell, 35(1), 111-124.e10
- Article Type
- We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs. © 2018 Elsevier Inc.Mun et al. perform proteogenomic analysis of diffuse gastric cancers (DGC) in a young population, identifying that correlations of mRNA-protein abundance associate with survival and defining four subtypes of DGC. The associations of some subtypes with related pathways are identified mainly by the proteomic data. © 2018 Elsevier Inc.
- Cell Press
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- Department of New BiologySystems Biology and Medicine Lab1. Journal Articles
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