Cited 6 time in webofscience Cited 7 time in scopus

Understanding the Role of the BAI Subfamily of Adhesion G Protein-Coupled Receptors (GPCRs) in Pathological and Physiological Conditions

Title
Understanding the Role of the BAI Subfamily of Adhesion G Protein-Coupled Receptors (GPCRs) in Pathological and Physiological Conditions
Authors
Moon, Sun YoungShin, Seong-AhOh, Yong-SeokPark, Hyun HoLee, Chang Sup
DGIST Authors
Oh, Yong-Seok
Issue Date
2018-12
Citation
Genes, 9(12), 597
Type
Article
Article Type
Review
Author Keywords
Apoptotic cell clearanceBrain-specific angiogenesis inhibitorEngulfmentTumorigenesis
Keywords
BRAIN-SPECIFIC ANGIOGENESISCASSETTE TRANSPORTER A1INHIBITOR-1 BAI1CELL CLEARANCEIN-VIVOEXPRESSIONGENEDISEASEVASCULOSTATINGLIOBLASTOMA
ISSN
2073-4425
Abstract
Brain-specific angiogenesis inhibitors (BAIs) 1, 2, and 3 are members of the adhesion G protein-coupled receptors, subfamily B, which share a conserved seven-transmembrane structure and an N-terminal extracellular domain. In cell-and animal-based studies, these receptors have been shown to play diverse roles under physiological and pathological conditions. BAI1 is an engulfment receptor and performs major functions in apoptotic-cell clearance and interacts (as a pattern recognition receptor) with pathogen components. BAI1 and-3 also participate in myoblast fusion. Furthermore, BAI1–3 have been linked to tumor progression and neurological diseases. In this review, we summarize the current understanding of the functions of BAI1–3 in pathological and physiological conditions and discuss future directions in terms of the importance of BAIs as pharmacological targets in diseases. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/9545
DOI
10.3390/genes9120597
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Related Researcher
  • Author Oh, Yong-Seok Molecular Psychiatry Lab
  • Research Interests Monoaminergic regulation of the CNS and mood;anxiety disorder; 모노아민 (세로토닌, 도파민)에 의한 신경조절과 기분;불안 장애 기전 연구
Files:
Collection:
Department of Brain and Cognitive SciencesMolecular Psychiatry Lab1. Journal Articles


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