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Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics

Title
Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics
Authors
Choi, Young InChoi, Eun-sookMun, Kwan HoLee, Se GeunLee, Sung JunJeong, Sang WonLee, Seung WooKim, Hyun-Chul
DGIST Authors
Lee, Se GeunLee, Sung JunJeong, Sang WonKim, Hyun-Chul
Issue Date
2019-04
Citation
Polymers, 11(4), 604
Type
Article
Article Type
Article
Author Keywords
gemini micellesdrug delivery systemsdisulfide–thiol exchangereactive oxygen species
Keywords
DRUG-DELIVERYCOPOLYMER MICELLESHYDROGEN-PEROXIDEBLOCK-COPOLYMERPOLYMERCANCERPEGNANOCARRIERSSURFACTANTSDESIGN
ISSN
2073-4360
Abstract
Polymeric micelles as drug delivery vehicles are popular owing to several advantages. In this study, a gemini amphiphile (gemini mPEG-Cys-PMT) consisting of hydrophilic poly(ethylene glycol) and hydrophobic poly(methionine) with cystine disulfide spacer was synthesized and its micellar properties for thiol- or reactive oxygen species (ROS)-dependent intracellular drug delivery were described. The cleavage of cystine linkage in a redox environment or the oxidation of methionine units in a ROS environment caused the destabilization of micelles. Such redox- or ROS-triggered micellar destabilization led to enhanced release of encapsulated doxorubicin (DOX) to induce cytotoxicity against cancer cells. Further, the therapeutic effects of the DOX-loaded micelles were demonstrated using the KB cell line. This study shows that thiol and ROS dual-responsive gemini micelles are promising platforms for nano-drug delivery in various cancer therapies. © 2019 by the authors.
URI
http://hdl.handle.net/20.500.11750/9875
DOI
10.3390/polym11040604
Publisher
MDPI
Related Researcher
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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