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Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics
- Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics
- Choi, Young In; Choi, Eun-sook; Mun, Kwan Ho; Lee, Se Geun; Lee, Sung Jun; Jeong, Sang Won; Lee, Seung Woo; Kim, Hyun-Chul
- DGIST Authors
- Lee, Se Geun; Lee, Sung Jun; Jeong, Sang Won; Kim, Hyun-Chul
- Issue Date
- Polymers, 11(4), 604
- Article Type
- Author Keywords
- gemini micelles; drug delivery systems; disulfide–thiol exchange; reactive oxygen species
- DRUG-DELIVERY; COPOLYMER MICELLES; HYDROGEN-PEROXIDE; BLOCK-COPOLYMER; POLYMER; CANCER; PEG; NANOCARRIERS; SURFACTANTS; DESIGN
- Polymeric micelles as drug delivery vehicles are popular owing to several advantages. In this study, a gemini amphiphile (gemini mPEG-Cys-PMT) consisting of hydrophilic poly(ethylene glycol) and hydrophobic poly(methionine) with cystine disulfide spacer was synthesized and its micellar properties for thiol- or reactive oxygen species (ROS)-dependent intracellular drug delivery were described. The cleavage of cystine linkage in a redox environment or the oxidation of methionine units in a ROS environment caused the destabilization of micelles. Such redox- or ROS-triggered micellar destabilization led to enhanced release of encapsulated doxorubicin (DOX) to induce cytotoxicity against cancer cells. Further, the therapeutic effects of the DOX-loaded micelles were demonstrated using the KB cell line. This study shows that thiol and ROS dual-responsive gemini micelles are promising platforms for nano-drug delivery in various cancer therapies. © 2019 by the authors.
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