이효상
Lee, Hyosang학력
- 1999 ~ 2006Johns Hopkins University 박사
- 1995 ~ 1997포항공과대학교 석사
- 1988 ~ 1995경북대학교 학사
경력
- 2015 ~ Current대구경북과학기술원 / 조교수
- 2007 ~ 2015캘리포니아공대 / 연구 조교수
- 2006 ~ 2006메사추세츠공대 / 박사 후 연구원
- 1997 ~ 1998경북대학교 의과대학교 / 조교
수상실적
- 2011NIH Pathway to Independence Award
- 2009Keystone Symposia Scholarship
- 2009Individual Grant Award
연구실 소개
- Laboratory of Affective Neuroscience
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1. Agony-related behaviors (pain and itch)Pain and itch are actual or imaginary unpleasant senses. While, physiologically, they are triggered by stimulating sensory neurons, they can be related to both sensory recognition and emotional process. In general, acute pain and itch occur within a short period of time and have clear causes. However, chronic pain and itch may last from a few weeks to several years without any definite causes. These chronic diseases often influence day-to-day of patients resulting in lethargy due to chronic fatigue, sever anxiety, depression, and even cognitive disorder. Our laboratory studies pain and itch sensory mechanisms of peripheral nervous system in molecular and circuitry level. Moreover, we aim to identify processing, regulating, and interacting mechanisms of pain and itch mediating circuits in the brain.
2. Social Behavior (aggression, sexual behavior, and social stress)As a social animal, human lives on its own and in a group while interacting with others. These interactions include all social behaviors that can affect or be affected by others. The outcome of such behaviors can be positive, negative, or neutral. Among these social behaviors, our laboratory focuses on the aggression, social stress elicited by aggression, and sexual behaviors in mouse model. Furthermore, we aim to identify brain regions and circuits mediating these behaviors, and develop techniques to regulate the behaviors by manipulating the responsible regions through optogenetics, chemogenetics, and cell-death tools.
3. Affective behaviors (obsessive compulsive behaviors, addiction, and feeding)
Affective disorders such as depression, obsessive compulsive disorder (OCD), and anxiety disorder are commonly occurring psychiatric diseases in modern society. These affective disorders can be expressed through anti-social behaviors, seizure, substance abuse, and eating disorder dangering individuals and the society. Causes of such disorders are known to be genetic and environmental. In the past, many efforts had been made to find treatments in molecular and genetic point of view. However, the current trend of psychiatric neurobiology begins to recognize and emphasize the importance of circuitry factors alongside genetic factors. Therefore, our laboratory studies affective behaviors through grooming, alcohol addiction, and feeding disorder mouse models. Furthermore, we aim to identify brain circuits and physiological mechanisms mediating such behaviors.
4. Neural circuitry, glial cells and neuroinflammationNeuroinflammation, an excessive immune activity in the brain, can be caused by infection, toxin, autoimmune disorder, metabolite, and traumatic stress. Recent studies recognize neuroinflammation as one of the major contributing factors of dementia, Parkinson’s disease, and other senile brain diseases and that it is closely related to post-traumatic stress disorder (PTSD), depression, and other psychiatric disorders. Moreover, this excessive immune activity in the brain is primarily regulated by astrocytes. The astrocyte is one of glial cells in the central nervous system and makes up most of the brain cells. Previously it was considered to regulate brain immune system and aid neuronal activity. However, many recent researches show astrocytes play a crucial role in physiological functions; brain homeostasis and neuronal plasticity. Our laboratory studies the astrocyte-mediated neuronal activity regulating mechanisms and aims to develop a treatment for neuroinflammation through optogenetics, chemogenetics, and cell-death tools.
Research Interests
Related Keyword
연구분야
미래유망 신기술(6T)
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20.
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201.
20115. 뇌신경과학연구
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국가과학기술표준분류
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OA. 뇌과학
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OA01. 뇌신경생물
OA0103. 시냅스 및 신경신호전달
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OA. 뇌과학
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OA01. 뇌신경생물
OA0105. 시스템통합조절 신경생물
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OA. 뇌과학
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OA03. 뇌의약
OA0304. 감각이상성 뇌질환
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