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Risks of suicide attempts after prescription of zolpidem in people with depression: A nationwide population study in South Korea

Title
Risks of suicide attempts after prescription of zolpidem in people with depression: A nationwide population study in South Korea
Authors
Kim, HyewonKim, YuwonMyung, WoojaeFava, MaurizioMischoulon, DavidLee, UnjooLee, HyosangNa, Eun JinChoi, Kwan WooShin, Myung-HeeJeon, Hong Jin
DGIST Authors
Lee, Hyosang
Issue Date
2020-03
Citation
Sleep, 43(3)
Type
Article
Article Type
Article
Author Keywords
suicide attemptzolpidemdepressionincidence rate ratios
Keywords
ASSOCIATIONDEATHPREDICTORMORTALITYFEELINGSINSOMNIAOVERDOSEBEHAVIORPERIODADULTS
ISSN
0161-8105
Abstract
OBJECTIVES: To investigate the association between zolpidem prescription and suicide attempts in people with depression. METHODS: A nationwide, population-based electronic medical records database from the Health Insurance Review & Assessment Service of South was used to investigate the incidence rate ratios (IRRs) of suicide attempts and probable suicide attempts in people with depression before and after zolpidem prescription using self-controlled case series design. RESULTS: In a total of 445 people who attempted suicide and 23 141 people who attempted probable suicide attempt, the IRRs of suicidal behavior during the risk periods before and after zolpidem prescription increased compared with those at the baseline. The IRRs gradually increased and peaked immediately before the prescription of zolpidem. The IRR was 70.06 (95% CI: 25.58-191.90) on day 2 before zolpidem prescription and 63.35 (95% CI: 22.99-174.59) on day 1 after zolpidem prescription in the suicide attempt group. The IRR was 24.07 (95% CI: 20.50-28.26) on the day before zolpidem prescription and 14.96 (95% CI: 12.21-18.34) on the day after zolpidem prescription in the probable suicide attempt group. The ratios declined eventually after zolpidem was prescribed. CONCLUSIONS: Although zolpidem prescription was associated with an increased risk of suicide attempts in people with depression, the risk increased and peaked immediately before zolpidem prescription. The risk declined gradually thereafter. This result indicates that the risk of suicide attempts increases at the time of zolpidem prescription. However, zolpidem prescription does not contribute to additional increase in the risk of suicide attempts. © Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.
URI
http://hdl.handle.net/20.500.11750/10991
DOI
10.1093/sleep/zsz235
Publisher
The American Academy of Sleep Medicine
Related Researcher
  • Author Lee, Hyosang Laboratory of Affective Neuroscience
  • Research Interests Neuronal circuit mechanisms underlying emotional behaviors; 정서적 행동을 매개하는 신경회로 연구
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesLaboratory of Affective Neuroscience1. Journal Articles


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