Cited 1 time in webofscience Cited 2 time in scopus

Magnetically Actuated Degradable Microrobots for Actively Controlled Drug Release and Hyperthermia Therapy

Title
Magnetically Actuated Degradable Microrobots for Actively Controlled Drug Release and Hyperthermia Therapy
Authors
Park, JongeonJin, Chae-wonLee, SeungminKim, Jin-YoungChoi, Hongsoo
DGIST Authors
Kim, Jin-YoungChoi, Hongsoo
Issue Date
2019-08
Citation
Advanced Healthcare Materials, 8(16), 1900213
Type
Article
Article Type
Article in press
Author Keywords
controlled releasedegradable compositesmagnetic actuationtargeted deliverytwo-photon polymerization
Keywords
IRON-OXIDE NANOPARTICLESPOLY(ETHYLENE GLYCOL)COMPOSITE NANOPARTICLESDELIVERYSYSTEMS5-FLUOROURACILFABRICATIONHYDROGELSPROPERTYSIZE
ISSN
2192-2640
Abstract
Microrobots facilitate targeted therapy due to their small size, minimal invasiveness, and precise wireless control. A degradable hyperthermia microrobot (DHM) with a 3D helical structure is developed, enabling actively controlled drug delivery, release, and hyperthermia therapy. The microrobot is made of poly(ethylene glycol) diacrylate (PEGDA) and pentaerythritol triacrylate (PETA) and contains magnetic Fe3O4 nanoparticles (MNPs) and 5-fluorouracil (5-FU). Its locomotion is remotely and precisely controlled by a rotating magnetic field (RMF) generated by an electromagnetic actuation system. Drug-free DHMs reduce the viability of cancer cells by elevating the temperature under an alternating magnetic field (AMF), a hyperthermic effect. 5-FU is released from the proposed DHMs in normal-, high-burst-, and constant-release modes, controlled by the AMF. Finally, actively controlled drug release from the DHMs in normal- and high-burst-release mode results in a reduction in cell viability. The reduction in cell viability is of greater magnitude in high-burst- than in normal-release mode. In summary, biodegradable DHMs have potential for actively controlled drug release and hyperthermia therapy. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
http://hdl.handle.net/20.500.11750/10379
DOI
10.1002/adhm.201900213
Publisher
John Wiley and Sons Ltd
Related Researcher
  • Author Choi, Hongsoo Bio-Micro Robotics Lab
  • Research Interests Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
Files:
There are no files associated with this item.
Collection:
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles


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