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A 3D Microscaffold Cochlear Electrode Array for Steroid Elution

Title
A 3D Microscaffold Cochlear Electrode Array for Steroid Elution
Authors
Jong, JongmoonKim, Jin-youngKim, Yeong CheolKim, SangwonChou, NamsunLee, SeungminChoung, Yun-HoonKim, SoheeBrugger, JuergenChoi, HongsooJang, Jeong Hun
DGIST Authors
Kim, Jin-youngKim, SoheeChoi, Hongsoo
Issue Date
2019-10
Citation
Advanced Healthcare Materials, 8(20)
Type
Article
Article Type
Article
Author Keywords
3D scaffoldsauditory brainstem responsecochlear implantsdexamethasoneMEMS electrode arrays
Keywords
INTRACOCHLEAR DRUG-DELIVERYROUND WINDOW DEXAMETHASONERESIDUAL HEARINGINSERTION TRAUMAIMPLANTPRESERVATIONSTIFFNESSSTRAIGHTFIBROSISSURVIVAL
ISSN
2192-2640
Abstract
In cochlear implants, the electrode insertion trauma during surgery can cause damage residual hearing. Preserving the residual hearing is an important challenge and the localized administration of drugs, such as steroids, is one of the most promising ways, but remains a challenge. Here, a microscaffold cochlear electrode array (MiSCEA) consisting of a microfabricated flexible electrode array and a 3D microscaffold for steroid reservoir is reported. The MiSCEA without loaded drug is tested by measuring the electrically evoked auditory brainstem response of the cochlea in guinea pigs (n = 4). The scaffold is then coated with steroid (dexamethasone) encapsulated in polylactic-co-glycolic acid and the continuous release of the steroid into artificial perilymph during six weeks is monitored. The steroid-containing scaffolds are then implanted into guinea pigs (n = 4) and threshold shifts are analyzed for four weeks by measuring the acoustically evoked auditory brainstem response. The threshold shifts tend to be lower in the group implanted with the steroid-containing MiSCEAs. The feasibility of 3D MiSCEA opens up the development of potential next-generation cochlear electrode with improved steroid release dynamics into cochlea. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
http://hdl.handle.net/20.500.11750/10880
DOI
10.1002/adhm.201900379
Publisher
John Wiley and Sons Ltd
Related Researcher
  • Author Kim, Sohee Neural Interfaces & MicroSystems Lab
  • Research Interests Neural interface; Brain interface; Bio MEMS; Soft MEMS; Stretchable electronics; Zebrafish electrophysiology
Files:
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Collection:
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles
Department of Robotics EngineeringNeural Interfaces & MicroSystems Lab1. Journal Articles
Department of Robotics EngineeringETC1. Journal Articles


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