Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Dokyung | ko |
dc.contributor.author | Bucher, Felicitas | ko |
dc.contributor.author | Ryu, Suyeon | ko |
dc.contributor.author | Jeong, Jongwon | ko |
dc.contributor.author | Lee, Beom Yong | ko |
dc.contributor.author | Jeong, Youngtae | ko |
dc.contributor.author | Kim, Minseok S. | ko |
dc.contributor.author | Oh, Yong-Seok | ko |
dc.contributor.author | Baek, Moon-Chang | ko |
dc.contributor.author | Yoon, Jong Hyuk | ko |
dc.contributor.author | Yea, Kyungmoo | ko |
dc.date.accessioned | 2019-12-12T08:48:38Z | - |
dc.date.available | 2019-12-12T08:48:38Z | - |
dc.date.created | 2019-10-24 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | Cytokine, v.126, pp.154863 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/10950 | - |
dc.description.abstract | Adiponectin (Ad) is a representative adipocytokine that regulates energy homeostasis including glucose transport and lipid oxidation through activation of AMP-activated protein kinase (AMPK) pathways. Plasma levels of Ad are reduced in obesity, which contributes to type 2 diabetes. Therefore, agents that activate the Ad signaling pathway could ameliorate metabolic diseases such as type 2 diabetes. Here, we report the identification of a high-affinitive agonist antibody against Ad receptors. The antibody was selected by using phage display of human combinatorial antibody libraries. The selected antibody induced phosphorylation of the acetyl-CoA carboxylase (ACC) and AMPK in skeletal muscle cells and stimulated glucose uptake and fatty-acid oxidation (FAO) in myotubes. In addition, the antibody significantly lowered blood glucose levels during a glucose challenge in normal mice as well as basal blood glucose levels in a type 2 diabetic mouse model. Taken together, these results suggest that the agonist antibody could be a promising therapeutic agent for the treatment of metabolic syndrome such as type 2 diabetes. © 2019 Elsevier Ltd | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.title | An adiponectin receptor agonist antibody stimulates glucose uptake and fatty-acid oxidation by activating AMP-activated protein kinase | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cyto.2019.154863 | - |
dc.identifier.wosid | 000509612400008 | - |
dc.identifier.scopusid | 2-s2.0-85073190347 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.contributor.nonIdAuthor | Jung, Dokyung | - |
dc.contributor.nonIdAuthor | Bucher, Felicitas | - |
dc.contributor.nonIdAuthor | Ryu, Suyeon | - |
dc.contributor.nonIdAuthor | Baek, Moon-Chang | - |
dc.contributor.nonIdAuthor | Yoon, Jong Hyuk | - |
dc.identifier.citationVolume | 126 | - |
dc.identifier.citationStartPage | 154863 | - |
dc.identifier.citationTitle | Cytokine | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Adiponectin | - |
dc.subject.keywordAuthor | Agonist antibody | - |
dc.subject.keywordAuthor | Diabetes | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | CELLS | - |
dc.contributor.affiliatedAuthor | Jeong, Youngtae | - |
dc.contributor.affiliatedAuthor | Kim, Minseok S. | - |
dc.contributor.affiliatedAuthor | Oh, Yong-Seok | - |
dc.contributor.affiliatedAuthor | Yea, Kyungmoo | - |
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