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Recent advances in melanin-like nanomaterials in biomedical applications: a mini review

Title
Recent advances in melanin-like nanomaterials in biomedical applications: a mini review
Authors
Park, JihyoMoon, HaeramHong, Seonki
DGIST Authors
Park, Jihyo; Moon, Haeram; Hong, Seonki
Issue Date
2019-12
Citation
Biomaterials Research, 23(1)
Type
Article
Article Type
Review
ISSN
2055-7124
Abstract
Background: Melanins are a group of biopigments in microorganisms that generate a wide range of colorants. Due to their multifunctionality, including ultraviolet protection, radical scavenging, and photothermal conversion, in addition to their intrinsic biocompatibility, natural melanins and synthetic melanin-like nanomaterials have been suggested as novel nano-bio platforms in biomedical applications. Main body: Recent approaches in the synthesis of melanin-like nanomaterials and their biomedical applications have briefly been reviewed. Melanin-like nanomaterials have been suggested as endogenous chromophores for photoacoustic imaging and radical scavengers for the treatment of inflammatory diseases. The photothermal conversion ability of these materials under near-infrared irradiation allows hyperthermia-mediated cancer treatments, and their intrinsic fluorescence can be an indicator in biosensing applications. Furthermore, catechol-rich melanin and melanin-like nanomaterials possess a versatile affinity for various functional organic and inorganic additives, allowing the design of multifunctional hybrid nanomaterials that expand their range of applications in bioimaging, therapy, theranostics, and biosensing. Conclusion: Melanin-like natural and synthetic nanomaterials have emerged; however, the under-elucidated chemical structures of these materials are still a major obstacle to the construction of novel nanomaterials through bottom-up approaches and tuning the material properties at the molecular level. Further advancements in melanin-based medical applications can be achieved with the incorporation of next-generation chemical and molecular analytical tools. © 2019 The Author(s).
URI
http://hdl.handle.net/20.500.11750/10996
DOI
10.1186/s40824-019-0175-9
Publisher
BioMed Central
Related Researcher
  • Author Hong, Seonki Biomaterials & Biointerface Engineering Laboratory
  • Research Interests Bio-inspired organic materials; Polymeric biomaterials; Surface biofunctionalization; biochip fabrication
Files:
Collection:
Department of Emerging Materials ScienceBiomaterials & Biointerface Engineering Laboratory1. Journal Articles


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