Cited 9 time in webofscience Cited 9 time in scopus

A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue

Title
A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue
Authors
Lee, SeungminKim, Jin-youngKim, JunyoungHoshiar, Ali KafashPark, JongeonLee, SunkeyKim, JonghyunPane, SalvadorNelson, Bradley J.Choi, Hongsoo
DGIST Authors
Kim, Jin-youngChoi, Hongsoo
Issue Date
2020-04
Citation
Advanced Healthcare Materials, 9(7), 1901697
Type
Article
Article Type
Article
Author Keywords
drug deliveryfixationmagnetic manipulationmicrorobotstargeted drug delivery
Keywords
ARTIFICIAL BACTERIAL FLAGELLAFABRICATIONTIME
ISSN
2192-2640
Abstract
A needle-type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO2) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 µm s−1 at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel-loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle-type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
http://hdl.handle.net/20.500.11750/11575
DOI
10.1002/adhm.201901697
Publisher
John Wiley and Sons Ltd
Related Researcher
  • Author Choi, Hongsoo Bio-Micro Robotics Lab
  • Research Interests Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
Files:
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Collection:
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles


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