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A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue
- Title
- A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue
- Authors
- Lee, Seungmin; Kim, Jin-young; Kim, Junyoung; Hoshiar, Ali Kafash; Park, Jongeon; Lee, Sunkey; Kim, Jonghyun; Pane, Salvador; Nelson, Bradley J.; Choi, Hongsoo
- DGIST Authors
- Lee, Seungmin; Kim, Jin-young; Kim, Junyoung; Hoshiar, Ali Kafash; Park, Jongeon; Lee, Sunkey; Kim, Jonghyun; Pane, Salvador; Nelson, Bradley J.; Choi, Hongsoo
- Issue Date
- 2020-04
- Citation
- Advanced Healthcare Materials, 9(7), 1901697
- Type
- Article
- Article Type
- Article
- Author Keywords
- drug delivery; fixation; magnetic manipulation; microrobots; targeted drug delivery
- Keywords
- ARTIFICIAL BACTERIAL FLAGELLA; FABRICATION; TIME
- ISSN
- 2192-2640
- Abstract
- A needle-type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO2) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 µm s−1 at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel-loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle-type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- URI
- http://hdl.handle.net/20.500.11750/11575
https://onlinelibrary.wiley.com/cms/asset/120d5e8d-aba2-48f3-a53b-0f3f29bfe090/adhm202070019-gra-0001-m.jpg
- DOI
- 10.1002/adhm.201901697
- Publisher
- John Wiley and Sons Ltd
- Related Researcher
-
- Files:
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- Collection:
- Department of Robotics and Mechatronics EngineeringBio-Micro Robotics Lab1. Journal Articles
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