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A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue

Title
A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue
Authors
Lee, SeungminKim, Jin-youngKim, JunyoungHoshiar, Ali KafashPark, JongeonLee, SunkeyKim, JonghyunPane, SalvadorNelson, Bradley J.Choi, Hongsoo
DGIST Authors
Lee, Seungmin; Kim, Jin-young; Kim, Junyoung; Hoshiar, Ali Kafash; Park, Jongeon; Lee, Sunkey; Kim, Jonghyun; Pane, Salvador; Nelson, Bradley J.; Choi, Hongsoo
Issue Date
2020-04
Citation
Advanced Healthcare Materials, 9(7), 1901697
Type
Article
Article Type
Article
Author Keywords
drug deliveryfixationmagnetic manipulationmicrorobotstargeted drug delivery
Keywords
ARTIFICIAL BACTERIAL FLAGELLAFABRICATIONTIME
ISSN
2192-2640
Abstract
A needle-type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO2) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 µm s−1 at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel-loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle-type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
http://hdl.handle.net/20.500.11750/11575
https://onlinelibrary.wiley.com/cms/asset/120d5e8d-aba2-48f3-a53b-0f3f29bfe090/adhm202070019-gra-0001-m.jpg
DOI
10.1002/adhm.201901697
Publisher
John Wiley and Sons Ltd
Related Researcher
Files:
There are no files associated with this item.
Collection:
Department of Robotics and Mechatronics EngineeringBio-Micro Robotics Lab1. Journal Articles


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