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3D-Printed Soft Magnetoelectric Microswimmers for Delivery and Differentiation of Neuron-Like Cells

Title
3D-Printed Soft Magnetoelectric Microswimmers for Delivery and Differentiation of Neuron-Like Cells
Authors
Dong, MeiWang, XiaopuChen, Xiang-ZhongMushtaq, FajerDeng, SiyuZhu, CaihongTorlakcik, HarunTerzopoulou, AnastasiaQin, Xiao-HuaXao, XuanzhoingPuigmarti-Luis, JosepChoi, HongsooPego, Ana PaulaShen, Qun-DongNelson, Bradley J.Pane, Salvador
DGIST Authors
Choi, Hongsoo
Issue Date
ACCEPT
Citation
Advanced Functional Materials, 1910323
Type
Article
Article Type
Article; Early Access
Author Keywords
magnetoelectricsmicrorobotsneuron cell differentiationpiezoelectricssoft robots
Keywords
MICROROBOTSDRUGNANOPARTICLESFABRICATIONALZHEIMERSRELEASEDEATH
ISSN
1616-301X
Abstract
Neurodegenerative diseases generally result in irreversible neuronal damage and neuronal death. Cell therapy shows promise as a potential treatment for these diseases. However, the therapeutic targeted delivery of these cells and the in situ provision of a suitable microenvironment for their differentiation into functional neuronal networks remain challenging. A highly integrated multifunctional soft helical microswimmer featuring targeted neuronal cell delivery, on-demand localized wireless neuronal electrostimulation, and post-delivery enzymatic degradation is introduced. The helical soft body of the microswimmer is fabricated by two-photon lithography of the photocurable gelatin–methacryloyl (GelMA)-based hydrogel. The helical body is then impregnated with composite multiferroic nanoparticles displaying magnetoelectric features (MENPs). While the soft GelMA hydrogel chassis supports the cell growth, and is degraded by enzymes secreted by cells, the MENPs allow for the magnetic transportation of the bioactive chassis, and act as magnetically mediated electrostimulators of neuron-like cells. The unique combination of the materials makes these microswimmers highly integrated devices that fulfill several requirements for their future translation to clinical applications, such as cargo delivery, cell stimulation, and biodegradability. The authors envision that these devices will inspire new avenues for targeted cell therapies for traumatic injuries and diseases in the central nervous system. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
http://hdl.handle.net/20.500.11750/11576
DOI
10.1002/adfm.201910323
Publisher
John Wiley & Sons Ltd.
Related Researcher
  • Author Choi, Hongsoo Bio-Micro Robotics Lab
  • Research Interests Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
Files:
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Collection:
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles


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