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dc.contributor.advisor 문인규 - Minwoo Sim - 2020-06-22T16:00:56Z - 2020-06-22T16:00:56Z - 2020 -
dc.identifier.uri en_US
dc.identifier.uri -
dc.description 적혈구세포 형상분석, 세포막 변동률 분석, 디지털 홀로그래픽 현미경, 항상성 -
dc.description.abstract The optimal functionality of red blood cells is closely associated with the surrounding environment. This study was undertaken to analyze the changes in membrane profile, mean hemoglobin content (MCH), and cell membrane fluctuations (CMF) of healthy red blood cells (RBC) at various temperatures. The temperature was elevated from 17℃ to 41℃ within a duration of less than one hour, and the holograms were recorded by a CCD camera in an off-axis digital holographic microscopy(DHM) system. After hologram reconstruction, we extracted single RBCs and evaluated their morphologically related features (projected surface area and sphericity coefficient), MCH, and CMF. We observed that elevating the temperature results in changes in the 3D profile. Since CMF amplitude is highly correlated to the bending curvature of RBC membrane, temperature-induced shape changes can alter CMF’s map and amplitude -
dc.description.abstract mainly larger fluctuations appear in dimple area at a higher temperature. Regardless of the shape changes, no alterations in MCH were seen with temperature variation. -
dc.description.statementofresponsibility open -
dc.description.tableofcontents Ⅰ. INTRODUCTION 1
1.1 Background 1
1.2 Label-free digital holographic imaging 3
2.1 Red blood cell sample preparations 7
3.1 Biochemical and morphological parameters 8
3.2 Discussions 10
3.2.1 RBC trapped between cover slip and glass 10
3.2.1 RBCs imaged on chamber 15
Abbreviations 18
References 19
dc.format.extent 29 -
dc.language eng -
dc.publisher DGIST -
dc.source /home/dspace/dspace53/upload/200000285143.pdf -
dc.title Red blood cell study at different temperatures with holographic imaging informatics -
dc.type Thesis -
dc.identifier.doi 10.22677/Theses.200000285143 -
dc.description.alternativeAbstract 본 논문에서는 적혈구의 기능이 주변환경과 밀접한 관계에 있는데, 디지털 홀로그래피와 영상처리 결합 기술 기반으로 온도변화에 따른 건강한 적혈구의 표면적, 평균 위상 값, 질량, 세포막 변동률 등과 같은 여러 중요 임상 파라미터 값들에 대한 특성 값을 정량적으로 분석하는 방법론을 제안하였으며, 흥미롭게도, 온도변화에 따른 적혈구세포의 형태학적인 특성 및 세포막 변동률 값 측정을 기반으로 적혈구세포의 구형 계수와 온도 간에 유의미한 상관 관계가 있음을 발견했다. 또한 온도가 높은 적혈구의 세포막 변동률 값이 온도가 낮은 경우보다 상대적으로 커짐을 발견하였으며, 그리고 온도 변화에 따라 모양 변화에 관계없이 적혈구세포의 질량의 변화는 나타나지 않음을 실험결과를 통하여 입증하였다. - Master -
dc.contributor.department Robotics Engineering -
dc.contributor.coadvisor Sanghyun Park - 2020-02 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.RM 심38 202002 - 2020-01-20 -
dc.contributor.alternativeDepartment 로봇공학전공 -
dc.contributor.affiliatedAuthor Park, Sanghyun -
dc.contributor.affiliatedAuthor Sim, Minwoo -
dc.contributor.affiliatedAuthor Moon, Inkyu -
dc.contributor.alternativeName 박상현 -
dc.contributor.alternativeName 심민우 -
dc.contributor.alternativeName Inkyu Moon -
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Department of Robotics and Mechatronics Engineering Theses Master


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