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Dysregulated Plasma Membrane Turnover Underlying Dendritic Pathology in Neurodegenerative Diseases

Title
Dysregulated Plasma Membrane Turnover Underlying Dendritic Pathology in Neurodegenerative Diseases
Authors
Chung, Chang GeonPark, Sung SoonPark, Jeong HyangLee, Sung Bae
DGIST Authors
Chung, Chang Geon; Park, Sung Soon; Park, Jeong Hyang; Lee, Sung Bae
Issue Date
2020-10
Citation
Frontiers in Cellular Neuroscience, 14, 556461
Type
Article
Article Type
Review
Author Keywords
plasma membrane turnoverdendritic pathologyneurodegenerative diseasesRab GTPasesdendritic secretory pathwaydendritic endocytic pathway
Keywords
CLATHRIN-COATED VESICLESER-EXIT SITESENDOPLASMIC-RETICULUMRAB GTPASESSPINE LOSSSECRETORY TRAFFICKINGENDOSOMAL TRAFFICKINGALZHEIMERS-DISEASEAMPA RECEPTORSMOUSE MODEL
ISSN
1662-5102
Abstract
Due to their enormous surface area compared to other cell types, neurons face unique challenges in properly handling supply and retrieval of the plasma membrane (PM)—a process termed PM turnover—in their distal areas. Because of the length and extensiveness of dendritic branches in neurons, the transport of materials needed for PM turnover from soma to distal dendrites will be inefficient and quite burdensome for somatic organelles. To meet local demands, PM turnover in dendrites most likely requires local cellular machinery, such as dendritic endocytic and secretory systems, dysregulation of which may result in dendritic pathology observed in various neurodegenerative diseases (NDs). Supporting this notion, a growing body of literature provides evidence to suggest the pathogenic contribution of dysregulated PM turnover to dendritic pathology in certain NDs. In this article, we present our perspective view that impaired dendritic endocytic and secretory systems may contribute to dendritic pathology by encumbering PM turnover in NDs. © 2020 Chung, Park, Park and Lee.
URI
http://hdl.handle.net/20.500.11750/12520
DOI
10.3389/fncel.2020.556461
Publisher
Frontiers Media S.A.
Related Researcher
  • Author Lee, Sung Bae Laboratory of Neurodegenerative Diseases and Aging
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
Files:
Collection:
Department of Brain SciencesLaboratory of Neurodegenerative Diseases and Aging1. Journal Articles


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