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Dysregulated Plasma Membrane Turnover Underlying Dendritic Pathology in Neurodegenerative Diseases
- Title
- Dysregulated Plasma Membrane Turnover Underlying Dendritic Pathology in Neurodegenerative Diseases
- Authors
- Chung, Chang Geon; Park, Sung Soon; Park, Jeong Hyang; Lee, Sung Bae
- DGIST Authors
- Chung, Chang Geon; Park, Sung Soon; Park, Jeong Hyang; Lee, Sung Bae
- Issue Date
- 2020-10
- Citation
- Frontiers in Cellular Neuroscience, 14, 556461
- Type
- Article
- Article Type
- Review
- Author Keywords
- plasma membrane turnover; dendritic pathology; neurodegenerative diseases; Rab GTPases; dendritic secretory pathway; dendritic endocytic pathway
- Keywords
- CLATHRIN-COATED VESICLES; ER-EXIT SITES; ENDOPLASMIC-RETICULUM; RAB GTPASES; SPINE LOSS; SECRETORY TRAFFICKING; ENDOSOMAL TRAFFICKING; ALZHEIMERS-DISEASE; AMPA RECEPTORS; MOUSE MODEL
- ISSN
- 1662-5102
- Abstract
- Due to their enormous surface area compared to other cell types, neurons face unique challenges in properly handling supply and retrieval of the plasma membrane (PM)—a process termed PM turnover—in their distal areas. Because of the length and extensiveness of dendritic branches in neurons, the transport of materials needed for PM turnover from soma to distal dendrites will be inefficient and quite burdensome for somatic organelles. To meet local demands, PM turnover in dendrites most likely requires local cellular machinery, such as dendritic endocytic and secretory systems, dysregulation of which may result in dendritic pathology observed in various neurodegenerative diseases (NDs). Supporting this notion, a growing body of literature provides evidence to suggest the pathogenic contribution of dysregulated PM turnover to dendritic pathology in certain NDs. In this article, we present our perspective view that impaired dendritic endocytic and secretory systems may contribute to dendritic pathology by encumbering PM turnover in NDs. © 2020 Chung, Park, Park and Lee.
- URI
- http://hdl.handle.net/20.500.11750/12520
- DOI
- 10.3389/fncel.2020.556461
- Publisher
- Frontiers Media S.A.
- Related Researcher
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Lee, Sung Bae
Laboratory of Neurodegenerative Diseases and Aging
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Research Interests
Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
- Files:
-
- Collection:
- Department of Brain SciencesLaboratory of Neurodegenerative Diseases and Aging1. Journal Articles
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