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dc.contributor.author Kim, Hee Young -
dc.contributor.author Um, Ji Won -
dc.contributor.author Ko, Jaewon -
dc.date.accessioned 2021-01-22T06:54:08Z -
dc.date.available 2021-01-22T06:54:08Z -
dc.date.created 2021-01-04 -
dc.date.created 2021-01-04 -
dc.date.created 2021-01-04 -
dc.date.created 2021-01-04 -
dc.date.issued 2021-05 -
dc.identifier.citation Progress in Neurobiology, v.200 -
dc.identifier.issn 0301-0082 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/12619 -
dc.description.abstract Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse development and specifying neural circuit properties via the formation of multifarious signaling pathways. Recent studies have pinpointed the putative roles of trans-synaptic cell-adhesion molecules in mediating various cognitive functions. Here, we review the literature on the roles of a diverse group of central synaptic organizers, including neurexins (Nrxns), leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs), and their associated binding proteins, in regulating properties of specific type of synapses and neural circuits. In addition, we highlight the findings that aberrant synaptic adhesion signaling leads to alterations in the structures, transmission, and plasticity of specific synapses across diverse brain areas. These results seem to suggest that proper trans-synaptic signaling pathways by Nrxns, LAR-RPTPs, and their interacting network is likely to constitute central molecular complexes that form the basis for cognitive functions, and that these complexes are heterogeneously and complexly disrupted in many neuropsychiatric and neurodevelopmental disorders. © 2020 Elsevier Ltd. All rights reserved. -
dc.language English -
dc.publisher Pergamon Press Ltd. -
dc.title Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function -
dc.type Article -
dc.identifier.doi 10.1016/j.pneurobio.2020.101983 -
dc.identifier.wosid 000636796000003 -
dc.identifier.scopusid 2-s2.0-85099619452 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Progress in Neurobiology -
dc.contributor.localauthor Kim, Hee Young -
dc.contributor.localauthor Um, Ji Won -
dc.contributor.localauthor Ko, Jaewon -
dc.contributor.nonIdAuthor Kim, Hee Young -
dc.identifier.citationVolume 200 -
dc.identifier.citationTitle Progress in Neurobiology -
dc.type.journalArticle Article in press -
dc.description.isOpenAccess N -
dc.subject.keywordAuthor synaptic adhesion -
dc.subject.keywordAuthor neurexin -
dc.subject.keywordAuthor LAR-RPTP -
dc.subject.keywordAuthor neural circuit -
dc.subject.keywordAuthor cognitive function -

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