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Computational Thermal Analysis of the Photothermal Effect of Thermoplasmonic Optical Fiber for Localized Neural Stimulation In Vivo

Title
Computational Thermal Analysis of the Photothermal Effect of Thermoplasmonic Optical Fiber for Localized Neural Stimulation In Vivo
Authors
Hong, WoongkiLee, JunheeKim, DuheeHwang, YujinKwon, Hyuk-JunJang, Jae EunKang, Hongki
DGIST Authors
Hong, Woongki; Lee, Junhee; Kim, Duhee; Hwang, Yujin; Kwon, Hyuk-JunJang, Jae EunKang, Hongki
Issue Date
2021-01
Citation
Electronics, 10(2), 118
Type
Article
Article Type
Article
Author Keywords
photothermal effectthermoplasmonicsfinite-element analysis (FEA)optical neuromodulationneural stimulation
ISSN
2079-9292
Abstract
Optical neuromodulation is a versatile neural stimulation technology that enables highly localized excitatory or inhibitory stimulation of neuronal activities. Photothermal neural stimulation using thermoplasmonic metallic nanoparticles for light to heat conversion has been suggested as an optical neural stimulation technology without genetic modification. Optical fibers implementing the thermoplasmonic effect were recently developed for localized neural stimulation, and the successful demonstration of localized neural stimulation in vitro was reported. However, before photothermal neural stimulation is further applied in the brains of live animals and ultimately in human trials, a safety analysis must carefully be performed for the thermal effect of stimulation in vivo. With the complexity of the physical structure and different thermal properties of the brain and surrounding body, the resulting thermal effect could vary despite the same power of light delivered to the optical fiber. In addition, dynamic thermal properties of the brain such as the daily blood perfusion rate change or metabolic heat generation must also be carefully considered for the precise implementation of photothermal neural stimulation. In this work, an in-depth computational analysis was conducted of the photothermal effects using a thermoplasmonic optical fiber for in vivo neural stimulation. The effects of the experimental design and stimulation protocols on the thermal effect in the brain were analyzed. We believe that the results provide a good experimental guideline for safely conducting photothermal neural stimulation using the thermoplasmonic optical fiber technology. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/12639
DOI
10.3390/electronics10020118
Publisher
MDPI AG
Related Researcher
  • Author Jang, Jae Eun Advanced Electronic Devices Research Group(AEDRG) - Jang Lab.
  • Research Interests Nanoelectroinc device; 생체 신호 센싱 시스템 및 생체 모방 디바이스; 나노 통신 디바이스
Files:
Collection:
Department of Electrical Engineering and Computer ScienceAdvanced Electronic Devices Research Group(AEDRG) - Kwon Lab.1. Journal Articles
Department of Electrical Engineering and Computer ScienceAdvanced Electronic Devices Research Group(AEDRG) - Jang Lab.1. Journal Articles
Department of Electrical Engineering and Computer ScienceAdvanced Electronic Devices Research Group(AEDRG) - Kang Lab.1. Journal Articles


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