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dc.contributor.author Lee, Jihun -
dc.contributor.author Lee, Hyoryong -
dc.contributor.author Kwon, Su-hyun -
dc.contributor.author Park, Sukho -
dc.date.accessioned 2021-01-22T07:10:18Z -
dc.date.available 2021-01-22T07:10:18Z -
dc.date.created 2020-10-26 -
dc.date.created 2020-10-26 -
dc.date.issued 2020-11 -
dc.identifier.citation Medical Engineering and Physics, v.85, pp.87 - 96 -
dc.identifier.issn 1350-4533 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/12686 -
dc.description.abstract In this paper, we propose the active delivery of multi-layer drug-loaded microneedle (MN) patches using a capsule that can be driven by an external magnetic field. Firstly, the multi-layer drug-loaded MN patches consist of three delivered MN patches which are composed of a drug-loaded MN patch and polydimethylsiloxane layer. The drug-loaded MN patch is made of a 10% gelatin solution and a drug. The multi-layer MN patches are attached to a permanent magnet in a magnetically driven capsule. Under an external magnetic field generated by an electromagnetic actuation system, the capsule with the multi-layer MN patches can reach the target lesions, and each MN patch can be delivered to the target lesions for medical treatment. The active delivery of the multi-layer MN patches using the proposed magnetically driven capsule was confirmed via phantom experiments. Accordingly, the adhesion of the three separated faces of the multi-layer MN patches and the adhesion between the porcine small intestine and the MN patch were measured using a load cell. We demonstrate the feasibility of the active delivery of the multi-layer MN patches to the target lesions on a porcine small intestine. Consequently, we expect that the active delivery of the multi-layer drug-loaded MN patches using the magnetically driven capsule presented in this study can be a useful method for drug delivery to lesions at various locations in the gastrointestinal tract. © 2020 -
dc.language English -
dc.publisher Elsevier BV -
dc.title Active delivery of multi-layer drug-loaded microneedle patches using magnetically driven capsule -
dc.type Article -
dc.identifier.doi 10.1016/j.medengphy.2020.09.012 -
dc.identifier.wosid 000579511600010 -
dc.identifier.scopusid 2-s2.0-85092274513 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Medical Engineering and Physics -
dc.contributor.localauthor Lee, Jihun -
dc.contributor.localauthor Lee, Hyoryong -
dc.contributor.localauthor Kwon, Su-hyun -
dc.contributor.localauthor Park, Sukho -
dc.contributor.nonIdAuthor Lee, Jihun -
dc.contributor.nonIdAuthor Lee, Hyoryong -
dc.contributor.nonIdAuthor Kwon, Su-hyun -
dc.identifier.citationVolume 85 -
dc.identifier.citationStartPage 87 -
dc.identifier.citationEndPage 96 -
dc.identifier.citationTitle Medical Engineering and Physics -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.subject.keywordAuthor Multi-layer microneedle -
dc.subject.keywordAuthor Magnetically driven capsule -
dc.subject.keywordAuthor Gastrointestinal drug delivery -
dc.subject.keywordAuthor Active drug delivery -
dc.subject.keywordPlus FABRICATION -
dc.subject.keywordPlus SYSTEM -

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