Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, Jihun | - |
dc.contributor.author | Lee, Hyoryong | - |
dc.contributor.author | Kwon, Su-hyun | - |
dc.contributor.author | Park, Sukho | - |
dc.date.accessioned | 2021-01-22T07:10:18Z | - |
dc.date.available | 2021-01-22T07:10:18Z | - |
dc.date.created | 2020-10-26 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | Medical Engineering and Physics, v.85, pp.87 - 96 | - |
dc.identifier.issn | 1350-4533 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/12686 | - |
dc.description.abstract | In this paper, we propose the active delivery of multi-layer drug-loaded microneedle (MN) patches using a capsule that can be driven by an external magnetic field. Firstly, the multi-layer drug-loaded MN patches consist of three delivered MN patches which are composed of a drug-loaded MN patch and polydimethylsiloxane layer. The drug-loaded MN patch is made of a 10% gelatin solution and a drug. The multi-layer MN patches are attached to a permanent magnet in a magnetically driven capsule. Under an external magnetic field generated by an electromagnetic actuation system, the capsule with the multi-layer MN patches can reach the target lesions, and each MN patch can be delivered to the target lesions for medical treatment. The active delivery of the multi-layer MN patches using the proposed magnetically driven capsule was confirmed via phantom experiments. Accordingly, the adhesion of the three separated faces of the multi-layer MN patches and the adhesion between the porcine small intestine and the MN patch were measured using a load cell. We demonstrate the feasibility of the active delivery of the multi-layer MN patches to the target lesions on a porcine small intestine. Consequently, we expect that the active delivery of the multi-layer drug-loaded MN patches using the magnetically driven capsule presented in this study can be a useful method for drug delivery to lesions at various locations in the gastrointestinal tract. © 2020 | - |
dc.language | English | - |
dc.publisher | Elsevier BV | - |
dc.title | Active delivery of multi-layer drug-loaded microneedle patches using magnetically driven capsule | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.medengphy.2020.09.012 | - |
dc.identifier.wosid | 000579511600010 | - |
dc.identifier.scopusid | 2-s2.0-85092274513 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Medical Engineering and Physics | - |
dc.contributor.nonIdAuthor | Lee, Jihun | - |
dc.contributor.nonIdAuthor | Lee, Hyoryong | - |
dc.contributor.nonIdAuthor | Kwon, Su-hyun | - |
dc.identifier.citationVolume | 85 | - |
dc.identifier.citationStartPage | 87 | - |
dc.identifier.citationEndPage | 96 | - |
dc.identifier.citationTitle | Medical Engineering and Physics | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Multi-layer microneedle | - |
dc.subject.keywordAuthor | Magnetically driven capsule | - |
dc.subject.keywordAuthor | Gastrointestinal drug delivery | - |
dc.subject.keywordAuthor | Active drug delivery | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.contributor.affiliatedAuthor | Lee, Jihun | - |
dc.contributor.affiliatedAuthor | Lee, Hyoryong | - |
dc.contributor.affiliatedAuthor | Kwon, Su-hyun | - |
dc.contributor.affiliatedAuthor | Park, Sukho | - |
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