Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Hwang, Yeo Jin | - |
dc.contributor.author | Gwon-Soo Jung | - |
dc.contributor.author | Jun-Hyuk Choi | - |
dc.contributor.author | Lee, Kyeong-Min | - |
dc.date.accessioned | 2021-01-22T07:29:14Z | - |
dc.date.available | 2021-01-22T07:29:14Z | - |
dc.date.created | 2020-11-19 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | BMB Reports, v.53, no.11, pp.594 - 599 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/12772 | - |
dc.description.abstract | Lin28a has diverse functions including regulation of cancer, reprogramming and regeneration, but whether it promotes injury or is a protective reaction to renal injury is unknown. We studied how Lin28a acts in unilateral ureteral obstruction (UUO)-induced renal fibrosis following unilateral ureteral obstruction, in a mouse model. We further defined the role of Lin28a in transforming growth factor (TGF)-signaling pathways in renal fibrosis through in vitro study using human tubular epithelium-like HK-2 cells. In the mouse unilateral ureteral obstruction model, obstruction markedly decreased the expression of Lin28a, increased the expression of renal fibrotic markers such as type I collagen, α-SMA, vimentin and fibronectin. In TGF-β-stimulated HK-2 cells, the expression of Lin28a was reduced and the expression of renal fibrotic markers such as type I collagen, α-SMA, vimentin and fibronectin was increased. Adenovirus-mediated overexpression of Lin28a inhibited the expression of TGF-?-stimulated type I collagen, α-SMA, vimentin and fibronectin. Lin28a inhibited TGF-β-stimulated SMAD3 activity, via inhibition of SMAD3 phosphorylation, but not the MAPK pathway ERK, JNK or p38. Lin28a attenuates renal fibrosis in obstructive nephropathy, making its mechanism a possible therapeutic target for chronic kidney disease. [BMB Reports 2020; 53(11): 594-599] © 2020 by the The Korean Society for Biochemistry and Molecular Biology | - |
dc.language | English | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Lin28a attenuates TGF-beta-induced renal fibrosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.5483/BMBRep.2020.53.11.153 | - |
dc.identifier.wosid | 000595589500006 | - |
dc.identifier.scopusid | 2-s2.0-85096886456 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | BMB Reports | - |
dc.identifier.kciid | ART002650377 | - |
dc.contributor.nonIdAuthor | Hwang, Yeo Jin | - |
dc.contributor.nonIdAuthor | Gwon-Soo Jung | - |
dc.contributor.nonIdAuthor | Jun-Hyuk Choi | - |
dc.identifier.citationVolume | 53 | - |
dc.identifier.citationNumber | 11 | - |
dc.identifier.citationStartPage | 594 | - |
dc.identifier.citationEndPage | 599 | - |
dc.identifier.citationTitle | BMB Reports | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Lin28a | - |
dc.subject.keywordAuthor | Renal fibrosis | - |
dc.subject.keywordAuthor | Renal tubular epithelial cell | - |
dc.subject.keywordAuthor | SMAD3 | - |
dc.subject.keywordAuthor | TGF-beta signaling | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | OBSTRUCTIVE NEPHROPATHY | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | LET-7 | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.contributor.affiliatedAuthor | Hwang, Yeo Jin | - |
dc.contributor.affiliatedAuthor | Gwon-Soo Jung | - |
dc.contributor.affiliatedAuthor | Jun-Hyuk Choi | - |
dc.contributor.affiliatedAuthor | Lee, Kyeong-Min | - |
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