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Recent Progress in Magnetically Actuated Microrobots for Targeted Delivery of Therapeutic Agents

Title
Recent Progress in Magnetically Actuated Microrobots for Targeted Delivery of Therapeutic Agents
Author(s)
Choi, JunheeHwang, JunsunKim, Jin-youngChoi, Hongsoo
Issued Date
2021-03
Citation
Advanced Healthcare Materials, v.10, no.6, pp.2001596
Type
Article
Author Keywords
cell deliverydrug deliverymagnetically actuatedmicrorobotstherapeutic agents
Keywords
DRUG-DELIVERYMAGNETOTACTIC BACTERIANEUTROPHIL RECRUITMENTCONTROLLED PROPULSIONMEDIATED DELIVERYMOTION CONTROLCARGOMANIPULATIONFABRICATIONNAVIGATION
ISSN
2192-2640
Abstract
Therapeutic agents, such as drugs and cells, play an essential role in virtually every treatment of injury, illness, or disease. However, the conventional practices of drug delivery often result in undesirable side effects caused by drug overdose and off-target delivery. In the case of cell delivery, the survival rate of the transplanted cells is extremely low and difficulties with the administration route of cells remain a problem. Recently, magnetically actuated microrobots have started offering unique opportunities in targeted therapeutic delivery due to their tiny size and ability to access hard-to-reach lesions in a minimally invasive manner; considerable advances in this regard have been made over the past decade. Here, recent progress in magnetically actuated microrobots, developed for targeted drug/cell delivery, is presented, with a focus on their design features and mechanisms for controlled therapeutic release. Additionally, the practical challenges faced by the microrobots, and future research directions toward the swift bench-to-bedside translation of the microrobots are addressed. © 2020 Wiley-VCH GmbH
URI
http://hdl.handle.net/20.500.11750/12933
DOI
10.1002/adhm.202001596
Publisher
John Wiley and Sons Ltd
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Appears in Collections:
Department of Robotics and Mechatronics Engineering Bio-Micro Robotics Lab 1. Journal Articles
Division of Biomedical Technology 1. Journal Articles

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