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Timely inhibitory circuit formation by Abl1 regulates innate olfactory behaviors in the mouse

Title
Timely inhibitory circuit formation by Abl1 regulates innate olfactory behaviors in the mouse
Authors
Kim, Jae YeonCho, BongkiMoon, Cheil
DGIST Authors
Kim, Jae Yeon; Cho, Bongki; Moon, Cheil
Issue Date
2019-09
Citation
IBRO Reports, 6, S209-S210
Type
Article
ISSN
2451-8301
Abstract
Over half of the interneurons in the mouse olfactory bulb (OB) are developed during the first week after birth, and dominantly connect to excitatory tufted cells near the superficial granule cell layer (sGCL), unlike late-born interneurons. However, the molecular mechanisms underlying the temporal specification have not been identified. Here, we discover the role of Abelson Tyrosine-Protein Kinase 1 (Abl1) in the temporal development of early-born OB interneurons. Lentiviral knockdown of Abl1 disrupts sGCL-specific circuit of the early-born interneurons by integratory and functional defects, resulting in olfactory hyper-sensitivity. From a proteomics approach, we find that Doublecortin (Dcx) is phosphorylated by Abl1, and which contributes to the stabilization of Dcx, thereby regulating microtubule dynamics. Finally, Dcx overexpression rescues Abl1-knockdown-induced anatomic or functional defects. In summary, we suggest that the specific signaling of Abl1-Dcx in early-born interneurons facilitates the temporal development of sGCL circuit for regulating innate olfactory functions, such as detection and sensitivity.
URI
http://hdl.handle.net/20.500.11750/13169
DOI
10.1016/j.ibror.2019.07.653
Publisher
Elsevier
Related Researcher
  • Author Moon, Cheil Laboratory of Chemical Senses
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
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Collection:
Division of Biotechnology1. Journal Articles
Department of Brain SciencesLaboratory of Chemical Senses1. Journal Articles


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