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dc.contributor.author Kim, Jae Yeon -
dc.contributor.author Cho, Bongki -
dc.contributor.author Moon, Cheil -
dc.date.accessioned 2021-04-23T05:15:38Z -
dc.date.available 2021-04-23T05:15:38Z -
dc.date.created 2019-10-04 -
dc.date.issued 2019-09 -
dc.identifier.citation IBRO Reports, v.6, pp.S209 - S210 -
dc.identifier.issn 2451-8301 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/13169 -
dc.description.abstract Over half of the interneurons in the mouse olfactory bulb (OB) are developed during the first week after birth, and dominantly connect to excitatory tufted cells near the superficial granule cell layer (sGCL), unlike late-born interneurons. However, the molecular mechanisms underlying the temporal specification have not been identified. Here, we discover the role of Abelson Tyrosine-Protein Kinase 1 (Abl1) in the temporal development of early-born OB interneurons. Lentiviral knockdown of Abl1 disrupts sGCL-specific circuit of the early-born interneurons by integratory and functional defects, resulting in olfactory hyper-sensitivity. From a proteomics approach, we find that Doublecortin (Dcx) is phosphorylated by Abl1, and which contributes to the stabilization of Dcx, thereby regulating microtubule dynamics. Finally, Dcx overexpression rescues Abl1-knockdown-induced anatomic or functional defects. In summary, we suggest that the specific signaling of Abl1-Dcx in early-born interneurons facilitates the temporal development of sGCL circuit for regulating innate olfactory functions, such as detection and sensitivity. -
dc.language English -
dc.publisher Elsevier -
dc.title Timely inhibitory circuit formation by Abl1 regulates innate olfactory behaviors in the mouse -
dc.type Article -
dc.identifier.doi 10.1016/j.ibror.2019.07.653 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname IBRO Reports -
dc.contributor.nonIdAuthor Kim, Jae Yeon -
dc.identifier.citationVolume 6 -
dc.identifier.citationStartPage S209 -
dc.identifier.citationEndPage S210 -
dc.identifier.citationTitle IBRO Reports -
dc.description.isOpenAccess Y -
dc.contributor.affiliatedAuthor Kim, Jae Yeon -
dc.contributor.affiliatedAuthor Cho, Bongki -
dc.contributor.affiliatedAuthor Moon, Cheil -
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Appears in Collections:
Department of Brain Sciences Laboratory of Chemical Senses 1. Journal Articles
Division of Biotechnology 1. Journal Articles

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