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Functionally associated classification of human olfactory receptor superfamily in the function associated manner

Title
Functionally associated classification of human olfactory receptor superfamily in the function associated manner
Authors
Choe, JiyunRyu, Sang EunBae, JisubShim, TammyMoon, Cheil
DGIST Authors
Choe, Jiyun; Ryu, Sang Eun; Bae, Jisub; Shim, Tammy; Moon, Cheil
Issue Date
2019-09
Citation
IBRO Reports, 6, S419
Type
Article
ISSN
2451-8301
Abstract
The odorant receptor (OR) is a main character in making olfactory sensory neurons (OSNs) activated by interacting with structurally diverse odorant molecules. Mammalian genomes of ORs are well established, and highly conserved regions within ORs have been identified. Numerous studies have focused on specific conserved amino acid motifs of ORs to examine their functional roles, which underlines their contribution to receptor functions. There are several variable regions among conserved motifs, and we found the patterns of variations within consensus amino acid sequences of the ORs. Based on our hypothesis that the related functions can be inferred from the pattern of variations in the conserved motifs of ORs, we performed hierarchical clustering of intact human OR proteins according to the concordance rate for selected conserved motifs. Human ORs were divided into two large groups, and classified into six sub-clusters according to the conserved patterns. We observed that the standard for dividing human ORs into two large groups is M (methionine) of PMLNPL/FIY, and verified the role of this region with selected representative OR models by conducting heterologous in vitro assay. This study proposed a new index for OR functions by presenting a conserved motif as a criterion for the classification of human OR families that cannot be fully explained by current classifications.
URI
http://hdl.handle.net/20.500.11750/13172
DOI
10.1016/j.ibror.2019.07.1330
Publisher
Elsevier
Related Researcher
  • Author Moon, Cheil Laboratory of Chemical Senses
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
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Collection:
Department of Brain SciencesLaboratory of Chemical Senses1. Journal Articles


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