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Plasma soluble neuregulin-1 as a diagnostic biomarker for Alzheimer's disease

Title
Plasma soluble neuregulin-1 as a diagnostic biomarker for Alzheimer's disease
Authors
Chang, Keun-AShin, Ki YoungNam, EunjooLee, Yeong-BaeMoon, Che IlSuh, Yoo-HunLee, Sang Hyung
DGIST Authors
Chang, Keun-A; Shin, Ki Young; Nam, Eunjoo; Lee, Yeong-Bae; Moon, Che Il; Suh, Yoo-Hun; Lee, Sang Hyung
Issue Date
2016-07
Citation
Neurochemistry International, 97, 1-7
Type
Article
Keywords
Alzheimer&aposs diseaseBeta amyloidSoluble NRG-1Blood plasmaBiomarker
Author Keywords
Alzheimer&aposs diseaseBeta amyloidSoluble NRG-1Blood plasmaBiomarker
Keywords
MILD COGNITIVE IMPAIRMENTAMYLOID-BETAINFLAMMATORY S100A9PERIPHERAL MARKERHEPARAN-SULFATESPINAL-CORDHUMAN BRAININ-VITROEXPRESSIONPROTEINS
ISSN
0197-0186
Abstract
To identify some apparent biomarker candidates for the diagnosis of Alzheimer's disease (AD) pathology, we investigated whether there would be a significant difference between the levels of the plasma proteins of AD patients and healthy people. A total of 115 subjects were enrolled, 60 individuals with AD and 55 healthy controls. There was a statistical difference in the mini-mental status exam (MMSE) scores and the clinical dementia rating (CDR) scores between the two groups. We used the immunoblotting assay to analyze several plasma proteins in the subjects. Amyloid-β (Aβ), S100a9, and soluble neuregulin-1 (sNRG-1), including α-synuclein (α-Syn) as a detection control were detected in the plasma samples. Unlike Aβ, S100a9 and α-Syn, the level of sNRG-1 of the AD patients was significantly higher than that of the healthy control subjects. The AD patients were divided into mild and moderate groups according to their MMSE and CDR scores. We found a significant correlation between the level of sNRG-1 and MMSE scores. The sNRG-1 level was significantly higher in mild AD patients as well as in moderate AD patients compared with that of the control subjects. These new findings indicate that increased plasma sNRG-1 levels might be a novel and reliable biological marker for the early diagnosis of AD. © 2016 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/13325
DOI
10.1016/j.neuint.2016.04.012
Publisher
Oxford [Elmsford, N. Y.] Pergamon Press.
Related Researcher
  • Author Moon, Cheil Laboratory of Chemical Senses
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
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Collection:
Department of Brain SciencesLaboratory of Chemical Senses1. Journal Articles


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