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dc.contributor.author Kim, Do Yun -
dc.contributor.author Lee, Sung Ho -
dc.contributor.author Kim, Jin Young -
dc.contributor.author Koo, Jae Hyung -
dc.contributor.author Kim, Soung-Min -
dc.contributor.author Kim, Kyung-Nyun -
dc.contributor.author Lee, Jong-Ho -
dc.contributor.author Jahng, Jeong Won -
dc.date.accessioned 2021-04-23T08:37:00Z -
dc.date.available 2021-04-23T08:37:00Z -
dc.date.created 2018-03-29 -
dc.date.issued 2015-06 -
dc.identifier.citation International Journal of Biosciences, v.6, no.11, pp.32 - 41 -
dc.identifier.issn 2220-6655 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/13333 -
dc.description.abstract This study investigated a causal relationship between anorexia and anhedonia in an animal model of stress, and
examined if the stress-induced anorexia and/or anhedonia is accompanied by changes in sweet receptor
expression in taste cells. Rats received daily injections of dexamethasone (0.1 or 1 mg/kg) or saline, mimicking
stress status. Anhedonia was assessed by measuring preferences for sweet and palatable foods at different time
points of drug injections. Rats were subjected to behavioral sessions to assess depression-like behaviors after 3
days or 4 weeks of daily drug injections. Decreased food intake was observed from the first day of
dexamethasone injection in a dose dependent manner, and persisted throughout the whole experimental period,
revealing anorectic property of the drug treatment. Sucrose preference was decreased in the 2nd week, and
cookie consumption on the 4th day, of drug treatment, as the earliest time point, respectively. Increased
immobility during forced swimming test was observed at the 3rd week, but not on the 4th day, of drug treatment.
Sweet receptors, T1R2 and T1R3, expression in the circumvallate papillae was not affected by dexamethasone
treatment. It is concluded that the development of anhedonia, possibly caused by anorexia, is a pre-symptomatic
feature of depression in rats treated with chronic dexamethasone, and its pathophysiologic mechanisms may not
comprise changes in sweet receptor expression in taste cells.
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dc.language English -
dc.publisher International Network for natural Sciences -
dc.title Anorexia, anhedonia and depression in rats by chronic dexamethasone. -
dc.type Article -
dc.identifier.doi 10.12692/ijb/6.11.32-41 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname International Journal of Biosciences -
dc.contributor.nonIdAuthor Kim, Do Yun -
dc.contributor.nonIdAuthor Lee, Sung Ho -
dc.contributor.nonIdAuthor Kim, Jin Young -
dc.contributor.nonIdAuthor Kim, Soung-Min -
dc.contributor.nonIdAuthor Kim, Kyung-Nyun -
dc.contributor.nonIdAuthor Lee, Jong-Ho -
dc.contributor.nonIdAuthor Jahng, Jeong Won -
dc.identifier.citationVolume 6 -
dc.identifier.citationNumber 11 -
dc.identifier.citationStartPage 32 -
dc.identifier.citationEndPage 41 -
dc.identifier.citationTitle International Journal of Biosciences -
dc.description.isOpenAccess Y -
dc.contributor.affiliatedAuthor Kim, Do Yun -
dc.contributor.affiliatedAuthor Lee, Sung Ho -
dc.contributor.affiliatedAuthor Kim, Jin Young -
dc.contributor.affiliatedAuthor Koo, Jae Hyung -
dc.contributor.affiliatedAuthor Kim, Soung-Min -
dc.contributor.affiliatedAuthor Kim, Kyung-Nyun -
dc.contributor.affiliatedAuthor Lee, Jong-Ho -
dc.contributor.affiliatedAuthor Jahng, Jeong Won -
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Department of New Biology Brain-Immune Axis Laboratory 1. Journal Articles

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