Spatial representation neuronal network modeling and in vitro formation on a substrate using a PDMS based physical structure

Abstract

Spatial representation network in the brain is operated by place cell and grid cell network interactions. For study about these cognitive functional mechanism, computation-al neuronal network modeling and in vitro neural network analysis platform are designed in terms of network motif. Computational modeling was tried to designed by neuron simu-lation tool, and for verifying this computational model, real pyramidal neuron was cultured in vitro that was extracted and dissected from rat. In vitro neuronal network pattering on microelectrode array (MEA) is the neuronal network analysis platform for investigating their neuronal activities, especially PDMS physical structure pattern on MEA for single cell level in vitro neuronal network for verifying previous computational neuronal network model. These single cell resolution modeling and analysis platform can be a tool for veri-fying and investigating about brain cognitive functions in terms of neural circuit approach of neuroscience. ⓒ 2015 DGIST