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Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types

Title
Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types
Authors
Zhang, HaiboPark, SongHuang, HaiKim, EungyungYi, JunkooChoi, Seong-KyoonRyoo, ZaeyoungKim, Myoungok
DGIST Authors
Zhang, Haibo; Park, Song; Huang, Hai; Kim, Eungyung; Yi, Junkoo; Choi, Seong-Kyoon; Ryoo, Zaeyoung; Kim, Myoungok
Issue Date
2021-04
Citation
Oncology Reports, 45(4), 33
Type
Article
Author Keywords
ginsenoside Rh2Panax ginsenganticancermechanismsreview
ISSN
1021-335X
Abstract
Ginsenoside Rh2 (G-Rh2) is a natural bioactive product derived from Panax ginseng Meyer (P. ginseng). G-Rh2 exhibits anticancer activity in various human cancer cell lines both in vitro and in vivo by modulating several signaling pathways, such as those of PDZ-binding kinase/T-LAK cell-originated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, mammalian target of rapamycin, epidermal growth factor receptor, p53, and reactive oxygen species. Moreover, G-Rh2 could effectively reverse drug resistance and enhance therapeutic effects in cancer therapy. This review summarizes the chemical properties, in vitro and in vivo anticancer activity, and underlying molecular mechanisms of G-Rh2 to facilitate cancer chemoprevention studies.
URI
http://hdl.handle.net/20.500.11750/13973
DOI
10.3892/or.2021.7984
Publisher
Spandidos Publications
Related Researcher
Files:
There are no files associated with this item.
Collection:
Division of Biotechnology1. Journal Articles


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