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dc.contributor.author Zhang, Haibo -
dc.contributor.author Yi, Jun Koo -
dc.contributor.author Huang, Hai -
dc.contributor.author Park, Sijun -
dc.contributor.author Kwon, Wookbong -
dc.contributor.author Kim, Eungyung -
dc.contributor.author Jang, Soyoung -
dc.contributor.author Kim, Si Yong -
dc.contributor.author Choi, Seong-Kyoon -
dc.contributor.author Yoon, Duhak -
dc.contributor.author Kim, Sung Hyun -
dc.contributor.author Liu, Kangdong -
dc.contributor.author Dong, Zigang -
dc.contributor.author Ryoo, Zae Young -
dc.contributor.author Kim, Myoung Ok -
dc.date.accessioned 2021-10-19T07:00:02Z -
dc.date.available 2021-10-19T07:00:02Z -
dc.date.created 2021-07-26 -
dc.date.issued 2022-05 -
dc.identifier.issn 1226-8453 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/15617 -
dc.description.abstract Background: Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is a natural compound extracted from ginseng, which exhibits anticancer effects in many cancer types. In this study, we demonstrated the effect and underlying molecular mechanism of G-Rh2 in CRC cells in vitro and in vivo. Methods: Cell proliferation, migration, invasion, apoptosis, cell cycle, and western blot assays were performed to evaluate the effect of G-Rh2 on CRC cells. In vitro pull-down assay was used to verify the interaction between G-Rh2 and Axl. Transfection and infection experiments were used to explore the function of Axl in CRC cells. CRC xenograft models were used to further investigate the effect of Axl knockdown and G-Rh2 on tumor growth in vivo. Results: G-Rh2 significantly inhibited proliferation, migration, and invasion, and induced apoptosis and G0/G1 phase cell cycle arrest in CRC cell lines. G-Rh2 directly binds to Axl and inhibits the Axl signaling pathway in CRC cells. Knockdown of Axl suppressed the growth, migration and invasion ability of CRC cells in vitro and xenograft tumor growth in vivo, whereas overexpression of Axl promoted the growth, migration, and invasion ability of CRC cells. Moreover, G-Rh2 significantly suppressed CRC xenograft tumor growth by inhibiting Axl signaling with no obvious toxicity to nude mice. Conclusion: Our results indicate that G-Rh2 exerts anticancer activity in vitro and in vivo by suppressing the Axl signaling pathway. G-Rh2 is a promising candidate for CRC prevention and treatment. © 2021 -
dc.language English -
dc.publisher Elsevier BV -
dc.title 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo -
dc.type Article -
dc.identifier.doi 10.1016/j.jgr.2021.07.004 -
dc.identifier.wosid 000799282500009 -
dc.identifier.scopusid 2-s2.0-85111036619 -
dc.identifier.bibliographicCitation Journal of Ginseng Research, v.46, no.3, pp.396 - 407 -
dc.identifier.kciid ART002839537 -
dc.description.isOpenAccess TRUE -
dc.subject.keywordAuthor Colorectal cancer -
dc.subject.keywordAuthor Xenograft -
dc.subject.keywordAuthor 20(S)-ginsenoside Rh2 -
dc.subject.keywordAuthor Axl -
dc.subject.keywordPlus RECEPTOR TYROSINE KINASE -
dc.subject.keywordPlus EGFR-TKI -
dc.subject.keywordPlus RESISTANCE -
dc.subject.keywordPlus PI3K/AKT -
dc.subject.keywordPlus SURVIVAL -
dc.subject.keywordPlus ERK1/2 -
dc.subject.keywordPlus SRC -
dc.subject.keywordPlus PROLIFERATION -
dc.subject.keywordPlus CHEMOTHERAPY -
dc.subject.keywordPlus ACTIVATION -
dc.citation.endPage 407 -
dc.citation.number 3 -
dc.citation.startPage 396 -
dc.citation.title Journal of Ginseng Research -
dc.citation.volume 46 -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.description.journalRegisteredClass kci -
dc.relation.journalResearchArea Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine -
dc.relation.journalWebOfScienceCategory Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine -
dc.type.docType Article -
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