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Noncytotoxic artificial bacterial flagella fabricated from biocompatible ORMOCOMP and iron coating

Noncytotoxic artificial bacterial flagella fabricated from biocompatible ORMOCOMP and iron coating
Qiu, FaminZhang, LiPeyer, Kathrin E.Casarosa, MarcoFranco-Obregon, AlfredoChoi, HongsooNelson, Bradley J.
DGIST Authors
Choi, Hongsoo
Issued Date
Article Type
Bacterial FlagellumBiocompatibilityBiomedical ApplicationsCell ViabilityCellsCoatingsHelmholtz CoilMagnetic ActuationMagnetic MicrorobotsMedical ApplicationsMinimally Invasive SurgeryPhotoresistsSwimming Performance
Magnetic microrobots have potential use in biomedical applications such as minimally invasive surgery, targeted diagnosis and therapy. Inspired by nature, artificial bacterial flagella (ABFs) are a form of microrobot powered by magnetic helical propulsion. For the promise of ABFs to be realized, issues of biocompatibility must be addressed and the materials used in their fabrication should be carefully considered. In this work, we fabricate the helical bodies of ABFs from a commercially available biocompatible photoresist, ORMOCOMP, by subsequently coating them with Fe for magnetic actuation. 3-(4,5- Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays show that Fe-coated ORMOCOMP layers do not undermine the cell viability during 72 hours of incubation compared to control substrates. Cells exhibit normal morphology on ABF arrays and show good lamellipodial and filopodial interactions with the ABF surfaces. The swimming performance of Fe-coated ABFs is characterized using a three-pair Helmholtz coil arrangement. ABFs exhibit a maximum forward speed of 48.9 μm s-1 under a field of 9 mT at a frequency of 72 Hz. In summary, our Fe-coated ABFs exhibit little cytotoxicity and have potential for in vivo applications, especially those involving difficult to access regions within the human body. © 2014 The Royal Society of Chemistry.
Royal Society of Chemistry
Related Researcher
  • 최홍수 Choi, Hongsoo 로봇및기계전자공학과
  • Research Interests Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
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Department of Robotics and Mechatronics Engineering Bio-Micro Robotics Lab 1. Journal Articles


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