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Ex Vivo Evaluation of Mechanical Anisotropic Tissues with High-Frequency Ultrasound Shear Wave Elastography

Ex Vivo Evaluation of Mechanical Anisotropic Tissues with High-Frequency Ultrasound Shear Wave Elastography
Lee, SeungyeopEun, Lucy YoungminHwang, Jae YounEun, Yongsoon
Issued Date
Sensors, v.22, no.3
Author Keywords
elastographymechanical anisotropyhigh-frequency ultrasoundmechanical wave imagingheart experimentcartilage experiment
The use of imaging devices to assess directional mechanics of tissues is highly desirable. This is because the directional mechanics depend on fiber orientation, and altered directional mechanics are closely related to the pathological status of tissues. However, measuring directional mechanics in tissues with high-stiffness is challenging due to the difficulty of generating localized displacement in these tissues using acoustic radiation force, a general method for generating displacement in ultrasound-based elastography. In addition, common ultrasound probes do not provide rotational function, which makes the measurement of directional mechanics inaccurate and unreliable. Therefore, we developed a high-frequency ultrasound mechanical wave elastography system that can accommodate a wide range of tissue stiffness and is also equipped with a motorized rotation stage for precise imaging of directional mechanics. A mechanical shaker was applied to the elastography system to measure tissues with high-stiffness. Phantom and ex vivo experiments were performed. In the phantom experiments, the lateral and axial resolution of the system were determined to be 144 µm and 168 µm, respectively. In the ex vivo experiments, we used swine heart and cartilage, both of which are considered stiff. The elastography system allows us to acquire the directional mechanics with high angular resolution in the heart and cartilage. The results demonstrate that the developed elastography system is capable of imaging a wide range of tissues and has high angular resolution. Therefore, this system might be useful for the diagnostics of mechanically anisotropic tissues via ex vivo tests. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Related Researcher
  • 황재윤 Hwang, Jae Youn 전기전자컴퓨터공학과
  • Research Interests Multimodal Imaging; High-Frequency Ultrasound Microbeam; Ultrasound Imaging and Analysis; 스마트 헬스케어; Biomedical optical system
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Appears in Collections:
Department of Electrical Engineering and Computer Science DSC Lab(Dynamic Systems and Control Laboratory) 1. Journal Articles
Department of Electrical Engineering and Computer Science MBIS(Multimodal Biomedical Imaging and System) Laboratory 1. Journal Articles


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