Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Shin, Sanghee | - |
dc.contributor.author | Jung, Inseong | - |
dc.contributor.author | Jung, Dokyung | - |
dc.contributor.author | Kim, Christine S. | - |
dc.contributor.author | Kang, Sung-Min | - |
dc.contributor.author | Ryu, Suyeon | - |
dc.contributor.author | Choi, Sung-Jin | - |
dc.contributor.author | Noh, Soojeong | - |
dc.contributor.author | Jeong, Jongwon | - |
dc.contributor.author | Lee, Beom Yong | - |
dc.contributor.author | Park, Jun-Kook | - |
dc.contributor.author | Shin, Jiwon | - |
dc.contributor.author | Cho, Hanchae | - |
dc.contributor.author | Heo, Jong-Ik | - |
dc.contributor.author | Jeong, Youngtae | - |
dc.contributor.author | Choi, Sun Ha | - |
dc.contributor.author | Lee, Shin Yup | - |
dc.contributor.author | Baek, Moon-Chang | - |
dc.contributor.author | Yea, Kyungmoo | - |
dc.date.accessioned | 2022-10-27T08:30:03Z | - |
dc.date.available | 2022-10-27T08:30:03Z | - |
dc.date.created | 2022-09-23 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/16960 | - |
dc.description.abstract | Extracellular vesicles (EVs) mediate cell-cell crosstalk by carrying bioactive molecules derived from cells. Recently, immune cell-derived EVs have been reported to regulate key biological functions such as tumor progression. CD4+ T cells orchestrate overall immunity; however, the biological role of their EVs is unclear. This study reveals that EVs derived from CD4+ T cells increase the antitumor response of CD8+ T cells by enhancing their proliferation and activity without affecting regulatory T cells (Tregs). Moreover, EVs derived from interleukin-2 (IL2)-stimulated CD4+ T cells induce a more enhanced antitumor response of CD8+ T cells compared with that of IL2-unstimulated CD4+ T cell-derived EVs. Mechanistically, miR-25-3p, miR-155-5p, miR-215-5p, and miR-375 within CD4+ T cell-derived EVs are responsible for the induction of CD8+ T cell-mediated antitumor responses. In a melanoma mouse model, the EVs potently suppress tumor growth through CD8+ T cell activation. This study demonstrates that the EVs, in addition to IL2, are important mediators between CD4+ and CD8+ T cells. Furthermore, unlike IL2, clinically used as an antitumor agent, CD4+ T cell-derived EVs stimulate CD8+ T cells without activating Tregs. Therefore, CD4+ T cell-derived EVs may provide a novel direction for cancer immunotherapy by inducing a CD8+ T cell-mediated antitumor response. © 2022 Elsevier Ltd | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.title | Novel antitumor therapeutic strategy using CD4+ T cell-derived extracellular vesicles | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2022.121765 | - |
dc.identifier.wosid | 000863239500003 | - |
dc.identifier.scopusid | 2-s2.0-85137022112 | - |
dc.identifier.bibliographicCitation | Biomaterials, v.289 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | Cancer immunotherapy | - |
dc.subject.keywordAuthor | Extracellular vesicles | - |
dc.subject.keywordAuthor | Interleukin-2 | - |
dc.subject.keywordAuthor | CD4+ T cells | - |
dc.subject.keywordAuthor | CD8+ T cells | - |
dc.subject.keywordPlus | INTERLEUKIN-2 | - |
dc.subject.keywordPlus | HELP | - |
dc.subject.keywordPlus | EXOSOMES | - |
dc.citation.title | Biomaterials | - |
dc.citation.volume | 289 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering; Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical; Materials Science, Biomaterials | - |
dc.type.docType | Article | - |
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