Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Jeon, Hyunbum | - |
dc.contributor.author | Kim, Yeo Jin | - |
dc.contributor.author | Hwang, Su-Kyeong | - |
dc.contributor.author | Seo, Jinsoo | - |
dc.contributor.author | Mun, Ji Young | - |
dc.date.accessioned | 2022-11-01T14:00:04Z | - |
dc.date.available | 2022-11-01T14:00:04Z | - |
dc.date.created | 2022-10-12 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/17016 | - |
dc.description.abstract | L-serine is a non-essential amino acid endogenously produced by astrocytes and is abundant in human diets. Beneficial roles of the metabolic products from L-serine in various conditions in the brain including neuronal development have been reported. Through several preclinical studies, L-serine treatment was also shown to offer beneficial therapeutic effects for brain damage such as ischemic stroke, amyotrophic lateral sclerosis, and Parkinson’s disease. Despite evidence for the value of L-serine in the clinic, however, its beneficial effects on the propionic acid (PPA)-induced neuronal toxicity and underlying mechanisms of L-serine-mediated neuroprotection are unknown. In this study, we observed that PPA-induced acidic stress induces abnormal lipid accumulation and functional defects in lysosomes of hippocampal neurons. L-serine treatment was able to rescue the structure and function of lysosomes in PPA-treated hippocampal neuronal cells. We further identified that L-serine suppressed the formation of lipid droplets and abnormal lipid membrane accumulations inside the lysosomes in PPA-treated hippocampal neuronal cells. Taken together, these findings indicate that L-serine can be utilized as a neuroprotective agent for the functionality of lysosomes through restoration of cathepsin D in disease conditions. © 2022 by the authors. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Restoration of Cathepsin D Level via L-Serine Attenuates PPA-Induced Lysosomal Dysfunction in Neuronal Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms231810613 | - |
dc.identifier.scopusid | 2-s2.0-85138341862 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.23, no.18 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | L-serine | - |
dc.subject.keywordAuthor | lysosome | - |
dc.subject.keywordAuthor | lipid droplet | - |
dc.subject.keywordAuthor | propionic acid (PPA) | - |
dc.subject.keywordAuthor | neuron | - |
dc.subject.keywordPlus | CHAIN FATTY-ACIDS | - |
dc.subject.keywordPlus | TRIACYLGLYCEROL ACCUMULATION | - |
dc.subject.keywordPlus | AMINO-ACID | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.citation.number | 18 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 23 | - |
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