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High-frequency dual mode pulsed wave Doppler imaging for monitoring the functional regeneration of adult zebrafish hearts

High-frequency dual mode pulsed wave Doppler imaging for monitoring the functional regeneration of adult zebrafish hearts
Kang, BJ[Kang, Bong Jin]Park, J[Park, Jinhyoung]Kim, J[Kim, Jieun]Kim, HH[Kim, Hyung Ham]Lee, C[Lee, Changyang]Hwang, JY[Hwang, Jae Youn]Lien, CL[Lien, Ching-Ling]Shung, KK[Shung, K. Kirk]
DGIST Authors
Hwang, JY[Hwang, Jae Youn]
Issued Date
Article Type
AmputationAnimal ExperimentAnimal ModelAnimaliaArtificial LimbsB ScanCoronary Artery Blood FlowDanio RerioDiastolic DysfunctionDopplerDoppler EchoDoppler EchocardiographyDoppler EchographyDoppler FlowDoppler FlowmetryDual Mode Pulsed Wave Doppler ImagingEchocardiographyFlow RateFlow VelocityFunctional RegenerationHeartHeart CycleHeart MovementHeart RegenerationHeart Valve MotionIn Vivo StudyLongitudinal StudyNon-HumanPhantomPost-Operative PeriodQuantitative AnalysisTissueTissue DopplerTissue Doppler ImagingTissue RegenerationUltrasonic ImagingUltrasound Imaging SystemsUltrasound TransducerZebrafishZebrafish Heart Regenerations
Adult zebrafish is a well-known small animal model for studying heart regeneration. Although the regeneration of scars made by resecting the ventricular apex has been visualized with histological methods, there is no adequate imaging tool for tracking the functional recovery of the damaged heart. For this reason, high-frequency Doppler echocardiography using dual mode pulsed wave Doppler, which provides both tissue Doppler (TD) and Doppler flow in a same cardiac cycle, is developed with a 30 MHz high-frequency array ultrasound imaging system. Phantom studies show that the Doppler flow mode of the dual mode is capable of measuring the flow velocity from 0.1 to 15 cm s(-1) with high accuracy (p-value = 0.974 > 0.05). In the in vivo study of zebrafish, both TD and Doppler flow signals were simultaneously obtained from the zebrafish heart for the first time, and the synchronized valve motions with the blood flow signals were identified. In the longitudinal study on the zebrafish heart regeneration, the parameters for diagnosing the diastolic dysfunction, for example, E/Em < 10, E/A < 0.14 for wild-type zebrafish, were measured, and the type of diastolic dysfunction caused by the amputation was found to be similar to the restrictive filling. The diastolic function was fully recovered within four weeks post-amputation. © 2014 The Author(s) Published by the Royal Society. All rights reserved.
Royal Society of Chemistry
Related Researcher
  • 황재윤 Hwang, Jae Youn 전기전자컴퓨터공학과
  • Research Interests Multimodal Imaging; High-Frequency Ultrasound Microbeam; Ultrasound Imaging and Analysis; 스마트 헬스케어; Biomedical optical system
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Department of Electrical Engineering and Computer Science MBIS(Multimodal Biomedical Imaging and System) Laboratory 1. Journal Articles


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