Cited time in webofscience Cited time in scopus

Mild hypothermia attenuates intercellular adhesion molecule-1 induction via activation of extracellular signal-regulated kinase-1/2 in a focal cerebral ischemia model

Title
Mild hypothermia attenuates intercellular adhesion molecule-1 induction via activation of extracellular signal-regulated kinase-1/2 in a focal cerebral ischemia model
Author(s)
Han, Hyung SooChoi, Jung SookPark, JaechanSuk, KyounghoMoon, CheilPark, Yong-Ki
Issued Date
2011
Citation
Stroke Research and Treatment, v.2011
Type
Article
Keywords
FACTOR-KAPPA-BTHERAPEUTIC HYPOTHERMIANEUTROPHIL INFILTRATIONINFLAMMATORY RESPONSESEXPERIMENTAL STROKELEUKOCYTE ADHESIONEXPRESSIONICAM-1ACCUMULATIONREPERFUSION
ISSN
2090-8105
Abstract
Intercellular adhesion molecule-1 (ICAM-1) in cerebral vascular endothelium induced by ischemic insult triggers leukocyte infiltration and inflammatory reaction. We investigated the mechanism of hypothermic suppression of ICAM-1 in a model of focal cerebral ischemia. Rats underwent 2 hours of middle cerebral artery occlusion and were kept at 37()C or 33()C during occlusion and rewarmed to normal temperature immediately after reperfusion. Under hypothermic condition, robust activation of extracellular signal-regulated kinase-1/2 (ERK1/2) was observed in vascular endothelium of ischemic brain. Hypothermic suppression of ICAM-1 was reversed by ERK1/2 inhibition. Phosphorylation of signal transducer and activator of transcription 3 (STAT3) in ischemic vessel was attenuated by hypothermia. STAT3 inhibitor suppressed ICAM-1 production induced by stroke. ERK1/2 inhibition enhanced phosphorylation and DNA binding activity of STAT3 in hypothermic condition. In this study, we demonstrated that hypothermic suppression of ICAM-1 induction is mediated by enhanced ERK1/2 activation and subsequent attenuation of STAT3 action. Copyright ? 2011 Jung Sook Choi et al.
URI
http://hdl.handle.net/20.500.11750/3480
DOI
10.4061/2011/846716
Publisher
Hindawi Publishing Corporation
Related Researcher
  • 문제일 Moon, Cheil
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files in This Item:
2_s2.0_79955069098.pdf

2_s2.0_79955069098.pdf

기타 데이터 / 3.09 MB / Adobe PDF download
Appears in Collections:
Department of Brain Sciences Laboratory of Chemical Senses 1. Journal Articles

qrcode

  • twitter
  • facebook
  • mendeley

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE