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dc.contributor.author Go, Gwangjun ko
dc.contributor.author Han, Jiwon ko
dc.contributor.author Zhen, Jin ko
dc.contributor.author Zheng, Shaohui ko
dc.contributor.author Yoo, Ami ko
dc.contributor.author Jeon, Mi-Jeong ko
dc.contributor.author Park, Jong-Oh ko
dc.contributor.author Park, Sukho ko
dc.date.available 2017-08-10T08:10:00Z -
dc.date.created 2017-08-09 -
dc.date.issued 2017-07 -
dc.identifier.citation Advanced Healthcare Materials, v.6, no.13 -
dc.identifier.issn 2192-2640 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/4131 -
dc.description.abstract This study proposes a magnetically actuated microscaffold with the capability of targeted mesenchymal stem cell (MSC) delivery for articular cartilage regeneration. The microscaffold, as a 3D porous microbead, is divided into body and surface portions according to its materials and fabrication methods. The microscaffold body, which consists of poly(lactic-co-glycolic acid) (PLGA), is formed through water-in-oil-in-water emulsion templating, and its surface is coated with amine functionalized magnetic nanoparticles (MNPs) via amino bond formation. The porous PLGA structure of the microscaffold can assist in cell adhesion and migration, and the MNPs on the microscaffold can make it possible to steer using an electromagnetic actuation system that provides external magnetic fields for the 3D locomotion of the microscaffold. As a fundamental test of the magnetic response of the microscaffold, it is characterized in terms of the magnetization curve, velocity, and 3D locomotion of a single microscaffold. In addition, its function with a cargo of MSCs for cartilage regeneration is demonstrated from the proliferation, viability, and chondrogenic differentiation of D1 mouse MSCs that are cultured on the microscaffold. For the feasibility tests for cartilage repair, 2D/3D targeting of multiple microscaffolds with the MSCs is performed to demonstrate targeted stem cell delivery using the microscaffolds and their swarm motion. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. -
dc.publisher Wiley-VCH Verlag -
dc.title Magnetically Actuated Microscaffold Containing Mesenchymal Stem Cells for Articular Cartilage Repair -
dc.type Article -
dc.identifier.doi 10.1002/adhm.201601378 -
dc.identifier.wosid 000404728600003 -
dc.identifier.scopusid 2-s2.0-85018418625 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.contributor.nonIdAuthor Go, Gwangjun -
dc.contributor.nonIdAuthor Han, Jiwon -
dc.contributor.nonIdAuthor Zhen, Jin -
dc.contributor.nonIdAuthor Zheng, Shaohui -
dc.contributor.nonIdAuthor Yoo, Ami -
dc.contributor.nonIdAuthor Jeon, Mi-Jeong -
dc.contributor.nonIdAuthor Park, Jong-Oh -
dc.identifier.citationVolume 6 -
dc.identifier.citationNumber 13 -
dc.identifier.citationTitle Advanced Healthcare Materials -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.subject.keywordPlus Amine -
dc.subject.keywordPlus Animal Cell -
dc.contributor.affiliatedAuthor Park, Sukho -
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Department of Robotics and Mechatronics Engineering Multiscale Biomedical Robotics Laboratory 1. Journal Articles

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