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dc.contributor.author Kim, Hojeong -
dc.date.available 2017-08-10T08:10:30Z -
dc.date.created 2017-08-09 -
dc.date.issued 2017-07 -
dc.identifier.issn 8750-7587 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/4140 -
dc.description.abstract Persistent inward current (PIC)- generating Cav1.3 channels in spinal motoneuron dendrites are thought to be actively recruited during normal behaviors. However, whether and how the activation of PIC channels influences force output of motor unit remains elusive. Here, building a physiologically realistic model of slow motor unit I demonstrated that force production induced by the PIC activation is much smaller for short than lengthened muscles during the regular firing of the motoneuron that transitions from the quiescent state by either a brief current pulse at the soma or a brief synaptic excitation at the dendrites. By contrast, the PIC-induced force potentiation was maximal for short muscles when the motoneuron switched from a stable low-frequency firing state to a stable high-frequency firing state by the current pulse at the soma. Under the synaptic excitation at the dendrites, however, the force could not be potentiated by the transitioning of the motoneuron from a low- to a high-frequency firing state due to the simultaneous onset of PIC at the dendrites and firing at the soma. The strong dependency of the input-output relationship of the motor unit on the neuromodulation and Ia afferent inputs for the PIC channels was further shown under static variations in muscle length. Taken together, these findings suggest that the PIC activation in the motoneuron dendrites may differentially affect the force production of the motor unit, depending not only on the firing state history of the motoneuron and the variation in muscle length but also on the mode of motor activity. NEW & NOTEWORTHY Cav1.3 channels in motoneuron dendrites are actively involved during normal motor activities. To investigate the effects of the activation of motoneuron Cav1.3 channels on force production, a model motor unit was built based on best-available data. The simulation results suggest that force potentiation induced by Cav1.3 channel activation is strongly modulated not only by firing history of the motoneuron but also by length variation of the muscle as well as neuromodulation inputs from the brainstem. Copyright © 2017 the American Physiological Society. -
dc.language English -
dc.publisher American Physiological Society -
dc.title Muscle length-dependent contribution of motoneuron Ca(v)1.3 channels to force production in model slow motor unit -
dc.type Article -
dc.identifier.doi 10.1152/japplphysiol.00491.2016 -
dc.identifier.scopusid 2-s2.0-85021878500 -
dc.identifier.bibliographicCitation Journal of Applied Physiology, v.123, no.1, pp.88 - 105 -
dc.subject.keywordAuthor spinal motoneuron -
dc.subject.keywordAuthor dendritic excitability -
dc.subject.keywordAuthor L-type Ca channel -
dc.subject.keywordAuthor force potentiation -
dc.subject.keywordAuthor motor unit -
dc.subject.keywordPlus Alpha Motoneurons -
dc.subject.keywordPlus Cat Soleus Muscle -
dc.subject.keywordPlus Dendritic Excitability -
dc.subject.keywordPlus Dynamic Model -
dc.subject.keywordPlus Force Potentiation -
dc.subject.keywordPlus Frog Skeletal Muscle -
dc.subject.keywordPlus In Vivo -
dc.subject.keywordPlus L Type Ca Channel -
dc.subject.keywordPlus Medial Gastrocnemius -
dc.subject.keywordPlus Motor Unit -
dc.subject.keywordPlus Persistent Inward Currents -
dc.subject.keywordPlus Plateau Like Behavior -
dc.subject.keywordPlus Spinal Motoneuron -
dc.subject.keywordPlus Spinal Motoneurons -
dc.subject.keywordPlus Systematic Variations -
dc.citation.endPage 105 -
dc.citation.number 1 -
dc.citation.startPage 88 -
dc.citation.title Journal of Applied Physiology -
dc.citation.volume 123 -
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Division of Biomedical Technology 1. Journal Articles

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