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DC Field Value Language Tong, Tao - Ryu, Sang Eun - Min, Yeojin - De March, Claire A. - Bushdid, Caroline - Golebiowski, Jerome - Moon, Cheil - Park, Taesun - 2017-09-11T04:39:33Z - 2017-09-11 - 2017 -
dc.identifier.citation Scientific Reports, v.7, no.1 -
dc.identifier.issn 2045-2322 -
dc.identifier.uri -
dc.description.abstract Ectopic expression and functions of odorant receptors (ORs) in the human body have aroused much interest in the past decade. Mouse olfactory receptor 23 (MOR23, olfr16) and its human orthologue, OR10J5, have been found to be functionally expressed in several non-olfactory systems. Here, using MOR23- and OR10J5-expressing Hana3A cells, we identified α-cedrene, a natural compound that protects against hepatic steatosis in mice fed the high-fat diet, as a novel agonist of these receptors. In human hepatocytes, an RNA interference-mediated knockdown of OR10J5 increased intracellular lipid accumulation, along with upregulation of lipogenic genes and downregulation of genes related to fatty acid oxidation. α-Cedrene stimulation resulted in a significant reduction in lipid contents of human hepatocytes and reprogramming of metabolic signatures, which are mediated by OR10J5, as demonstrated by receptor knockdown experiments using RNA interference. Taken together, our findings show a crucial role of OR10J5 in the regulation of lipid accumulation in human hepatocytes. © 2017 The Author(s). -
dc.language English -
dc.publisher Nature Publishing Group -
dc.title Olfactory receptor 10J5 responding to Alpha-cedrene regulates hepatic steatosis via the cAMP-PKA pathway -
dc.type Article -
dc.identifier.doi 10.1038/s41598-017-10379-x -
dc.identifier.wosid 000408448600008 -
dc.identifier.scopusid 2-s2.0-85028418996 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Scientific Reports -
dc.contributor.nonIdAuthor Tong, Tao -
dc.contributor.nonIdAuthor Ryu, Sang Eun -
dc.contributor.nonIdAuthor Min, Yeojin -
dc.contributor.nonIdAuthor De March, Claire A. -
dc.contributor.nonIdAuthor Bushdid, Caroline -
dc.contributor.nonIdAuthor Golebiowski, Jerome -
dc.contributor.nonIdAuthor Park, Taesun -
dc.identifier.citationVolume 7 -
dc.identifier.citationNumber 1 -
dc.identifier.citationTitle Scientific Reports -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.contributor.affiliatedAuthor Tong, Tao -
dc.contributor.affiliatedAuthor Ryu, Sang Eun -
dc.contributor.affiliatedAuthor Min, Yeojin -
dc.contributor.affiliatedAuthor De March, Claire A. -
dc.contributor.affiliatedAuthor Bushdid, Caroline -
dc.contributor.affiliatedAuthor Golebiowski, Jerome -
dc.contributor.affiliatedAuthor Moon, Cheil -
dc.contributor.affiliatedAuthor Park, Taesun -
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Department of Brain Sciences Laboratory of Chemical Senses 1. Journal Articles


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