The neurophysiological characterization of local organelle-coordinated interplay in Drosophila neurons
- Title
- The neurophysiological characterization of local organelle-coordinated interplay in Drosophila neurons
- Author(s)
- Davin Lee
- DGIST Authors
- Davin Lee ; Sung Bae Lee ; Daeyoup Lee
- Advisor
- 이성배
- Co-Advisor(s)
- Daeyoup Lee
- Issued Date
- 2024
- Awarded Date
- 2024-02-01
- Type
- Thesis
- Description
- Golgi outpost;Early endosomes;hybrid organelle;Rab19;pollux
- Table Of Contents
-
List of Contents
Abstract i
List of contents ii
List of tables iii
List of figures vi
Ⅰ. Introduction
1.1 Elucidating Cooperative Subcellular Compartmentalization in Eukaryotic Organelles 1
1.2 Integral Functions of Miniature Satellite Organelles in Neuronal Intracellular Architecture and the Shaping of Dendritic Complexity 2
1.3 Regulation of Golgi Outposts: de novo Synthesis vs. Somatic Golgi Apparatus Fission in Neuronal Cells 3
1.4 The Regulatory Switch for Golgi Outpost Biogenesis: The Role of Dendritic Rab19 in Drosophila Neuronal Cells 4
ⅠI. Materials and Methods 6
ⅠII. Results
3.1 Decreased activity of Rab19 increases the number of GOPs in dendrites 11
3.2 Early endosomes are closely associated with the formation of GOPs 33
3.3 A Rab19 GAP, pollux, is involved in the generation of GOPs and dendritic localization of Rab19 59
ⅠV. Discussions 75
V. References 78
VI. Summary in Korean 80
- URI
-
http://hdl.handle.net/20.500.11750/48000
http://dgist.dcollection.net/common/orgView/200000729372
- Degree
- Doctor
- Department
- Department of Brain Sciences
- Publisher
- DGIST
- Related Researcher
-
-
Lee, Sung Bae
- Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
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- Files in This Item:
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- Appears in Collections:
- Department of Brain Sciences Theses Ph.D.
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