Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Ban, H. Y. | - |
dc.contributor.author | Schweiger, M. | - |
dc.contributor.author | Kavuri, V. C. | - |
dc.contributor.author | Cochran, J. M. | - |
dc.contributor.author | Xie, L. | - |
dc.contributor.author | Busch, D. R. | - |
dc.contributor.author | Katrasnik, J. | - |
dc.contributor.author | Pathak, S. | - |
dc.contributor.author | Chung, S. H. | - |
dc.contributor.author | Lee, Kijoon | - |
dc.contributor.author | Choe, R. | - |
dc.contributor.author | Czerniecki, B. J. | - |
dc.contributor.author | Arridge, S. R. | - |
dc.contributor.author | Yodh, A. G. | - |
dc.date.accessioned | 2018-01-25T01:08:08Z | - |
dc.date.available | 2018-01-25T01:08:08Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.issn | 0094-2405 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/5098 | - |
dc.description.abstract | Purpose: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. Methods: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of sourcedetector pairs (106). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. Results: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. Conclusions: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated. © 2016 American Association of Physicists in Medicine. | - |
dc.language | English | - |
dc.publisher | American Association of Physicists in Medicine | - |
dc.title | Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry | - |
dc.type | Article | - |
dc.identifier.doi | 10.1118/1.4953830 | - |
dc.identifier.scopusid | 2-s2.0-84976363328 | - |
dc.identifier.bibliographicCitation | Medical Physics, v.43, no.7, pp.4383 - 4395 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | diffuse optical tomography | - |
dc.subject.keywordAuthor | optical mammography | - |
dc.subject.keywordAuthor | breast cancer imaging | - |
dc.subject.keywordAuthor | CCD-based optical tomography instrumentation | - |
dc.subject.keywordPlus | NEOADJUVANT CHEMOTHERAPY | - |
dc.subject.keywordPlus | FLUORESCENCE CONTRAST | - |
dc.subject.keywordPlus | HEALTHY BREAST | - |
dc.subject.keywordPlus | TURBID MEDIA | - |
dc.subject.keywordPlus | MAMMOGRAPHY | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | SPECTROSCOPY | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordPlus | DENSITY | - |
dc.citation.endPage | 4395 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 4383 | - |
dc.citation.title | Medical Physics | - |
dc.citation.volume | 43 | - |
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