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Glutathione-Responsive Gemini Polymeric Micelles as Controlled Drug Carriers

Title
Glutathione-Responsive Gemini Polymeric Micelles as Controlled Drug Carriers
Authors
Kim, Hyun-ChulKim, EunjooJeong, Sang WonLee, Se GuenLee, Sung JunLee, Seung Woo
DGIST Authors
Kim, Hyun-ChulKim, EunjooJeong, Sang WonLee, Se GuenLee, Sung Jun
Issue Date
2015-02
Citation
Macromolecular Research, 23(2), 196-204
Type
Article
Article Type
Article
Keywords
Amino AcidsControlled Drug DeliveryCovalent BondsCritical Micelle Concentration (CMC)CystinesCytotoxicityDisulfide-Thiol ExchangeDisulfide-Thiol ExchangesDrug DeliveryDrug Delivery SystemDrug ProductsGemini SurfactantGemini SurfactantsGSH ConcentrationsIntracellular CompartmentsLoadingMicellesMicroscopic ObservationsPeptidesPolyethylene GlycolsPolymersPolyolsPolypeptidePolypeptidesStimuli-Sensitive PolymersSulfur Compounds
ISSN
1598-5032
Abstract
Gemini poly(ethylene glycol)-cystine-poly(s-butyl cysteine) ((PEG)2-Cyt-(PBC)2) with a cystine disulfide bond as a spacer was prepared via oxidation of the cysteine group of monomeric poly(ethylene glycol)-cysteine-poly(s-butyl cysteine) (PEG-Cys-PBC) in solution, which is specifically cleavable in intracellular compartments. Due to its amphiphilic nature, (PEG)2-Cyt-(PBC)2 formed micelles under aqueous conditions; the average diameter of the micelles was 26.9 nm. The critical micelle concentration (CMC) of the polymer was 15.8 mg/L. The loading content of the chosen model drug, indomethacine (IMC), was much higher for gemini micelles than that for monomeric micelles. The (PEG)2-Cyt-(PBC)2 micelles released 75% of the loaded IMC within 72 h under 10 mM glutathione (GSH), whereas 36% of the loaded IMC was released from the micelles in the absence of GSH. An in vitro cytotoxicity experiment revealed that PTX-loaded gemini micelles showed toxicity to A549 cells with increasing GSH concentrations. Microscopic observation of gemini micelles demonstrated that the micelles containing a disulfide bond could effectively deliver the drug into A549 cells. These results suggest the potential of disulfide-based gemini polymeric micelles as controlled drug delivery carriers.[Figure not available: see fulltext.] © 2015, The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht.
URI
http://hdl.handle.net/20.500.11750/5207
DOI
10.1007/s13233-015-3030-4
Publisher
Polymer Society of Korea
Related Researcher
  • Author Kim, Eunjoo  
  • Research Interests Biomarker, liquid biopsy, nanomedicine, molecular diagnosis
Files:
There are no files associated with this item.
Collection:
Magnet-Controlled Materials Research Group1. Journal Articles
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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