Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun Chul | - |
dc.contributor.author | Kim, Eun Joo | - |
dc.contributor.author | Ha, Tae Lin | - |
dc.contributor.author | Lee, Se Geun | - |
dc.contributor.author | Lee, Seong Jun | - |
dc.contributor.author | Jeong, Sang Won | - |
dc.date.accessioned | 2018-02-05T04:12:10Z | - |
dc.date.available | 2018-02-05T04:12:10Z | - |
dc.date.created | 2018-01-01 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | Polymer, v.133, pp.102 - 109 | - |
dc.identifier.issn | 0032-3861 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/5630 | - |
dc.description.abstract | The synthesis of a novel polymeric surfactant with a repeating disulfide-based gemini structure (poly( gemini surfactant)) and its micellar properties for GSH-dependent intracellular drug delivery are described. A linear polyethylene glycol (PEG) was end-functionalized with N-stearoylcysteine and the cysteine thiol groups of the telechelic surfactant were oxidized intermolecularly in the micellar state to produce poly(gemini surfactant). Compared with the telechelic surfactant, poly(gemini surfactant) possessed a lower critical micelle concentration and higher solubilization capacity for doxorubicin (DOX). Moreover, the poly(gemini surfactant) micelles revealed excellent colloidal stability against excess sodium dodecyl sulfate (SDS) as a micelle-destabilizing agent. Cytotoxicity experiments showed that poly(gemini surfactant) composed of PEG, cysteine, and stearic acid was virtually non-cytotoxic up to 100 mg L-1. In the presence of glutathione (GSH), poly(gemini surfactant) was degraded back into the telechelic surfactant, leading to the release of encapsulated DOX to induce cytotoxicity against cancer cells. © 2017 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | Elsevier BV | - |
dc.title | Highly stable and reduction responsive micelles from a novel polymeric surfactant with a repeating disulfide-based gemini structure for efficient drug delivery | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.polymer.2017.11.032 | - |
dc.identifier.wosid | 000417165000011 | - |
dc.identifier.scopusid | 2-s2.0-85034420347 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Polymer | - |
dc.contributor.nonIdAuthor | Ha, Tae Lin | - |
dc.identifier.citationVolume | 133 | - |
dc.identifier.citationStartPage | 102 | - |
dc.identifier.citationEndPage | 109 | - |
dc.identifier.citationTitle | Polymer | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Polymeric micelles | - |
dc.subject.keywordAuthor | Gemini structures | - |
dc.subject.keywordAuthor | Reduction-responsive | - |
dc.subject.keywordPlus | CROSS-LINKED MICELLES | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER MICELLES | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | SPACER | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | AGENTS | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Kim, Eun Joo | - |
dc.contributor.affiliatedAuthor | Ha, Tae Lin | - |
dc.contributor.affiliatedAuthor | Lee, Se Geun | - |
dc.contributor.affiliatedAuthor | Lee, Seong Jun | - |
dc.contributor.affiliatedAuthor | Jeong, Sang Won | - |
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