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Gas bubbles induced by combined optical and ultrasound energies for high-resolution deep optical microscopy

Title
Gas bubbles induced by combined optical and ultrasound energies for high-resolution deep optical microscopy
Author(s)
Kim, JinwooKim, JuhwanKim, HaeminChang, Jin Ho
Issued Date
2024-07
Citation
APL Photonics, v.9, no.7
Type
Article
Keywords
HIGH-SPEED OBSERVATIONCAVITATIONMULTIPHOTON MICROSCOPY
ISSN
2378-0967
Abstract
Ultrasound-induced optical clearing microscopy (US-OCM) addresses limited imaging depth in optical microscopy, caused by light scattering in biological tissues. It uses ultrasound-induced gas bubbles to better image biological samples. However, controlling the bubble location using only ultrasound is challenging. This study introduces a novel method, “optrasound,” combining optical and ultrasound energies for precise bubble control. It presents the ultrasound field and uses a focused laser to trigger bubble formation. Optrasound-induced deep microscopy improves light beam width by 3.39 times at a depth of 350 µm because the gas bubbles reduce light scattering. This technique can precisely localize a bubble cloud while matching the US-OCM performance. © 2024 Author(s).
URI
http://hdl.handle.net/20.500.11750/57227
DOI
10.1063/5.0203205
Publisher
American Institute of Physics
Related Researcher
  • 장진호 Chang, Jin Ho
  • Research Interests Biomedical Imaging; Signal and Image Processing; Ultrasound Imaging System; Ultrasound Transducer; Photoacoustic Imaging
Files in This Item:
001281663100002.pdf

001281663100002.pdf

기타 데이터 / 9.95 MB / Adobe PDF download
Appears in Collections:
Department of Electrical Engineering and Computer Science Medical Acoustic Fusion Innovation Lab. 1. Journal Articles

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