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Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics

Title
Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics
Authors
Noh, Kyung NimPark, Sung IlQazi, RazaZou, ZhananMickle, Aaron D.Grajales-Reyes, Jose G.Jang, Kyung InGereau, Robert W.Xiao, JianliangRogers, John A.Jeong, Jae-Woong
DGIST Authors
Jang, Kyung In
Issue Date
2018-01
Citation
Small, 14(4)
Type
Article
Article Type
Article
Keywords
FLEXIBLE NEURAL PROBESIN-VIVOMICROFLUIDIC CHANNELSCIRCUITSOPTOELECTRONICSNEUROSCIENCEFABRICATIONIMPLANTSPARYLENEDELIVERY
ISSN
1613-6810
Abstract
Combination of optogenetics and pharmacology represents a unique approach to dissect neural circuitry with high specificity and versatility. However, conventional tools available to perform these experiments, such as optical fibers and metal cannula, are limited due to their tethered operation and lack of biomechanical compatibility. To address these issues, a miniaturized, battery-free, soft optofluidic system that can provide wireless drug delivery and optical stimulation for spatiotemporal control of the targeted neural circuit in freely behaving animals is reported. The device integrates microscale inorganic light-emitting diodes and microfluidic drug delivery systems with a tiny stretchable multichannel radiofrequency antenna, which not only eliminates the need for bulky batteries but also offers fully wireless, independent control of light and fluid delivery. This design enables a miniature (125 mm3), lightweight (220 mg), soft, and flexible platform, thus facilitating seamless implantation and operation in the body without causing disturbance of naturalistic behavior. The proof-of-principle experiments and analytical studies validate the feasibility and reliability of the fully implantable optofluidic systems for use in freely moving animals, demonstrating its potential for wireless in vivo pharmacology and optogenetics. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
http://hdl.handle.net/20.500.11750/5805
DOI
10.1002/smll.201702479
Publisher
WILEY-V C H VERLAG GMBH
Related Researcher
  • Author Jang, Kyung-In Bio-embedded Electronics Lab
  • Research Interests Extreme mechanics; Stand-alone electronics; Heterogeneous materials; Biocompatible interfaces
Files:
There are no files associated with this item.
Collection:
Department of Robotics EngineeringBio-embedded Electronics Lab1. Journal Articles


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