Title

Drug screening system using zebrafish EEG and its application to anti-epileptic drug screening

DGIST Authors

Junnyeong Shin ; Sohee Kim ; Seokhyung Kim

Advisor

김소희

Co-Advisor(s)

Seokhyung Kim

Issued Date

2025

Awarded Date

2025-08-01

Type

Thesis

Description

Zebrafish, EEG, Anti-epileptic drugs, Drug screening, Efficacy

Table Of Contents

Chapter Ⅰ. Introduction 9
1. Background. 10
1.1 Challenges in epilepsy and anti-epileptic-drug (AED) development 10
1.2 Pre-clinical epilepsy models: strengths and limitations 10
1.3 Zebrafish as a model for neurological disease 11
1.4 EEG-based functional endpoints in zebrafish epilepsy research 11
2. Objectives of this research 12
Chapter Ⅱ. Methods 14
1. EEG measurement system of adult zebrafish 15
2. EEG measurement system of larvae zebrafish 17
Chapter Ⅲ. AED screening using EEG from chemically-induced epileptic zebrafish model 20
1. Introduction 21
2. Method 22
3. Result and Discussion 24
4. Conclusion 36
Chapter Ⅳ. AED screening using EEG from genetic epileptic zebrafish model 37
1. Introduction 38
2. Method 39
3. Result and Discussion 42
4. Conclusion 54
Chapter Ⅴ. Conclusion and Future directions 55
1. Conclusion and discussion 56
2. Limitation and Future direction 57
3. References 58
요약문 64

URI

https://scholar.dgist.ac.kr/handle/20.500.11750/59768
http://dgist.dcollection.net/common/orgView/200000893936

DOI

10.22677/THESIS.200000893936

Degree

Doctor

Department

Department of Robotics and Mechatronics Engineering

Publisher

DGIST

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