Title

Inhibitory Interneurons in the Mediodorsal Nucleus of the Thalamus and their Modulation and Termination of Short-Term Memory

DGIST Authors

ChaeWon Kang ; Cheil Moon ; Jong-Cheol Rah

Advisor

문제일

Co-Advisor(s)

Jong-Cheol Rah

Issued Date

2025

Awarded Date

2025-08-01

Type

Thesis

Description

mediodorsal thalamus(MD), inhibitory interneuron, short-term memory, thalamofrontal circuit, short-term plasticity

Table Of Contents

List of Contents
Abstract i
List of contents ii
List of figures iii

Ⅰ. Introduction
1.1 The role of short-term memory in cognitive processing 1
1.2 Local inhibitory mechanisms underlying STM termination 4
1.3 Synaptic mechanisms for STM modulation 6

ⅠI. Methods
2.1 Animal 8
2.2 Viral vectors and stereotactic surgery 8
2.3 Electrophysiology 9
2.3.1 Slice preparation 9
2.3.2 Electrophysiological recordings 10
2.3.3 Drug application 10
2.4 Immunohistochemistry 10
2.5 Data analysis 11
2.5.1 Acquisition 11
2.5.2 Statistics 12

ⅠII. Results
3.1 The existence of inhibitory interneurons in MD 13
3.2 Intrinsic properties of PV+ interneurons of MD 14
3.3 Strong short-term synaptic facilitation in MDIN· 15
3.4 MDINmediated feedforward inhibition of MDEX 15
3.5 Dendrodendritic synaptic morphology of MDIN 16

IV. Figures
Figure 1. The existence of inhibitory interneurons in the MD thalamus.
Figure 2. Intrinsic electrophysiological properties of MD neurons.
Figure 3. mPFC-to-MDIN synapses facilitate sustained high-frequency activity.
Figure 4. MDIN inhibits MDEX as high-frequency PFC activity continues.
Figure 5. The local synaptic connections within the MD thalamus.

URI

https://scholar.dgist.ac.kr/handle/20.500.11750/59807
http://dgist.dcollection.net/common/orgView/200000892353

DOI

10.22677/THESIS.200000892353

Degree

Master

Department

Department of Brain Sciences

Publisher

DGIST

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