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An SU-8-based microprobe with a nanostructured surface enhances neuronal cell attachment and growth

Title
An SU-8-based microprobe with a nanostructured surface enhances neuronal cell attachment and growth
Authors
Kim, Eun HeeKim, Jin YoungChoi, Hong Soo
DGIST Authors
Kim, Jin YoungChoi, Hong Soo
Issue Date
2017-12
Citation
Micro and Nano Systems Letters, 5(28), 1-8
Type
Article
Article Type
Article
ISSN
2213-9621
Abstract
Microprobes are used to repair neuronal injury by recording electrical signals from neuronal cells around the surface of the device. Following implantation into the brain, the immune response results in formation of scar tissue around the microprobe. However, neurons must be in close proximity to the microprobe to enable signal recording. A common reason for failure of microprobes is impaired signal recording due to scar tissue, which is not related to the microprobe itself. Therefore, the device–cell interface must be improved to increase the number of neurons in contact with the surface. In this study, we developed nanostructured SU-8 microprobes to support neuronal growth. Nanostructures of 200 nm diameter and depth were applied to the surface of microprobes, and the attachment and neurite outgrowth of PC12 cells on the microprobes were evaluated. Neuronal attachment and neurite outgrowth on the nanostructured microprobes were significantly greater than those on non-nanostructured microprobes. The enhanced neuronal attachment and neurite outgrowth on the nanostructured microprobes occurred in the absence of an adhesive coating, such as poly-l-lysine, and so may be useful for implantable devices for long-term use. Therefore, nanostructured microprobes can be implanted without adhesive coating, which can cause problems in vivo over the long term. © The Author(s) 2017
URI
http://hdl.handle.net/20.500.11750/6165
DOI
10.1186/s40486-017-0062-x
Publisher
Springer Open
Related Researcher
  • Author Choi, Hongsoo Bio-Micro Robotics Lab
  • Research Interests Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
Files:
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Collection:
DGIST-ETH Microrobotics Research Center1. Journal Articles
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles


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