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An SU-8-based microprobe with a nanostructured surface enhances neuronal cell attachment and growth
- An SU-8-based microprobe with a nanostructured surface enhances neuronal cell attachment and growth
- Kim, Eun Hee; Kim, Jin Young; Choi, Hong Soo
- DGIST Authors
- Kim, Jin Young; Choi, Hong Soo
- Issue Date
- Micro and Nano Systems Letters, 5(1), 28
- Article Type
- Author Keywords
- Surface modifcation; Nanostructured surface; Nanosphere lithography; Cell attachment; Neurite outgrowth
- Microprobes are used to repair neuronal injury by recording electrical signals from neuronal cells around the surface of the device. Following implantation into the brain, the immune response results in formation of scar tissue around the microprobe. However, neurons must be in close proximity to the microprobe to enable signal recording. A common reason for failure of microprobes is impaired signal recording due to scar tissue, which is not related to the microprobe itself. Therefore, the device–cell interface must be improved to increase the number of neurons in contact with the surface. In this study, we developed nanostructured SU-8 microprobes to support neuronal growth. Nanostructures of 200 nm diameter and depth were applied to the surface of microprobes, and the attachment and neurite outgrowth of PC12 cells on the microprobes were evaluated. Neuronal attachment and neurite outgrowth on the nanostructured microprobes were significantly greater than those on non-nanostructured microprobes. The enhanced neuronal attachment and neurite outgrowth on the nanostructured microprobes occurred in the absence of an adhesive coating, such as poly-l-lysine, and so may be useful for implantable devices for long-term use. Therefore, nanostructured microprobes can be implanted without adhesive coating, which can cause problems in vivo over the long term. © 2017, The Author(s).
- Related Researcher
Bio-Micro Robotics Lab
Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
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- Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles
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