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dc.contributor.author Kim, Eun Hee -
dc.contributor.author Kim, Jin Young -
dc.contributor.author Choi, Hong Soo -
dc.date.accessioned 2018-04-11T03:46:49Z -
dc.date.available 2018-04-11T03:46:49Z -
dc.date.created 2018-03-29 -
dc.date.issued 2017-12 -
dc.identifier.citation Micro and Nano Systems Letters, v.5, no.1, pp.28 -
dc.identifier.issn 2213-9621 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/6165 -
dc.description.abstract Microprobes are used to repair neuronal injury by recording electrical signals from neuronal cells around the surface of the device. Following implantation into the brain, the immune response results in formation of scar tissue around the microprobe. However, neurons must be in close proximity to the microprobe to enable signal recording. A common reason for failure of microprobes is impaired signal recording due to scar tissue, which is not related to the microprobe itself. Therefore, the device–cell interface must be improved to increase the number of neurons in contact with the surface. In this study, we developed nanostructured SU-8 microprobes to support neuronal growth. Nanostructures of 200 nm diameter and depth were applied to the surface of microprobes, and the attachment and neurite outgrowth of PC12 cells on the microprobes were evaluated. Neuronal attachment and neurite outgrowth on the nanostructured microprobes were significantly greater than those on non-nanostructured microprobes. The enhanced neuronal attachment and neurite outgrowth on the nanostructured microprobes occurred in the absence of an adhesive coating, such as poly-l-lysine, and so may be useful for implantable devices for long-term use. Therefore, nanostructured microprobes can be implanted without adhesive coating, which can cause problems in vivo over the long term. © 2017, The Author(s). -
dc.language English -
dc.publisher Springer -
dc.title An SU-8-based microprobe with a nanostructured surface enhances neuronal cell attachment and growth -
dc.type Article -
dc.identifier.doi 10.1186/s40486-017-0062-x -
dc.identifier.scopusid 2-s2.0-85050372434 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Micro and Nano Systems Letters -
dc.contributor.nonIdAuthor Kim, Eun Hee -
dc.identifier.citationVolume 5 -
dc.identifier.citationNumber 1 -
dc.identifier.citationStartPage 28 -
dc.identifier.citationTitle Micro and Nano Systems Letters -
dc.type.journalArticle Article -
dc.embargo.liftdate 9999-12-31 -
dc.embargo.terms 9999-12-31 -
dc.description.isOpenAccess Y -
dc.subject.keywordAuthor Surface modifcation -
dc.subject.keywordAuthor Nanostructured surface -
dc.subject.keywordAuthor Nanosphere lithography -
dc.subject.keywordAuthor Cell attachment -
dc.subject.keywordAuthor Neurite outgrowth -
dc.contributor.affiliatedAuthor Kim, Eun Hee -
dc.contributor.affiliatedAuthor Kim, Jin Young -
dc.contributor.affiliatedAuthor Choi, Hong Soo -
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Appears in Collections:
Department of Robotics and Mechatronics Engineering Bio-Micro Robotics Lab 1. Journal Articles

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