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Recent Advances in Studies on the Therapeutic Potential of Dietary Carotenoids in Neurodegenerative Diseases

Title
Recent Advances in Studies on the Therapeutic Potential of Dietary Carotenoids in Neurodegenerative Diseases
Authors
Cho, Kyoung SangShin, MyeongcheolKim, SunhongLee, Sung Bae
DGIST Authors
Lee, Sung Bae
Issue Date
2018-04
Citation
Oxidative Medicine and Cellular Longevity, 2018, 4120458
Type
Article
Article Type
Review
Keywords
NF-KAPPA-BAMYOTROPHIC-LATERAL-SCLEROSISPERFORMANCE LIQUID-CHROMATOGRAPHYEXPERIMENTAL PARKINSONS-DISEASEINDUCED HUNTINGTONS-DISEASEINDUCED OXIDATIVE STRESSRAT CORTICAL-NEURONSALZHEIMERS-DISEASEBETA-CAROTENEVITAMIN-A
ISSN
1942-0900
Abstract
Carotenoids, symmetrical tetraterpenes with a linear C40 hydrocarbon backbone, are natural pigment molecules produced by plants, algae, and fungi. Carotenoids have important functions in the organisms (including animals) that obtain them from food. Due to their characteristic structure, carotenoids have bioactive properties, such as antioxidant, anti-inflammatory, and autophagy-modulatory activities. Given the protective function of carotenoids, their levels in the human body have been significantly associated with the treatment and prevention of various diseases, including neurodegenerative diseases. In this paper, we review the latest studies on the effects of carotenoids on neurodegenerative diseases in humans. Furthermore, animal and cellular model studies on the beneficial effects of carotenoids on neurodegeneration are also reviewed. Finally, we discuss the possible mechanisms and limitations of carotenoids in the treatment and prevention of neurological diseases.
URI
http://hdl.handle.net/20.500.11750/6404
DOI
10.1155/2018/4120458
Publisher
HINDAWI LTD
Related Researcher
  • Author Lee, Sung Bae Laboratory of Neurodegenerative Diseases and Aging
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
Files:
Collection:
Department of Brain and Cognitive SciencesLaboratory of Neurodegenerative Diseases and Aging1. Journal Articles


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