Cited 3 time in webofscience Cited 3 time in scopus

Interleukin-5 suppresses Vascular Endothelial Growth Factor-induced angiogenesis through STAT5 signaling

Title
Interleukin-5 suppresses Vascular Endothelial Growth Factor-induced angiogenesis through STAT5 signaling
Authors
Bucher, FelicitasLee, JunghoShin, SangheeKim, Minseok S.Oh, Yong-SeokHa, SanghoonZhang, HongkaiYea, Kyungmoo
DGIST Authors
Kim, Minseok S.Oh, Yong-SeokYea, Kyungmoo
Issue Date
2018-10
Citation
Cytokine, 110, 397-403
Type
Article
Article Type
Article in Press
Keywords
Interleukin-5VEGFAngiogenesisEndothelialSTAT5
ISSN
1043-4666
Abstract
Interleukin-5 (IL-5) is best known as key regulator in eosinophil-associated diseases such as asthma. While a connection to vascular changes in eosinophil-associated lung diseases is still elusive, recent evidence suggests that IL-5 may have an atheroprotective role. Here, we report an unexpected anti-angiogenic potential of IL-5 on vascular endothelial cells in vitro. IL-5 significantly inhibited fundamental functions of human lung microvascular endothelial cells (HMVEC-L) in vessel formation including VEGF-induced endothelial cell proliferation, migration and tube formation. Knockdown (KD) of STAT5 abolished the direct anti-angiogenic effect of IL-5 on VEGF-induced endothelial cell proliferation, migration and tube formation. © 2018 Elsevier Ltd
URI
http://hdl.handle.net/20.500.11750/6663
DOI
10.1016/j.cyto.2018.06.021
Publisher
Academic Press
Related Researcher
  • Author Oh, Yong-Seok Molecular Psychiatry Lab
  • Research Interests Monoaminergic regulation of the CNS and mood;anxiety disorder; 모노아민 (세로토닌, 도파민)에 의한 신경조절과 기분;불안 장애 기전 연구
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Collection:
Department of Brain and Cognitive SciencesMolecular Psychiatry Lab1. Journal Articles
Department of New BiologyProtein Engineering Lab1. Journal Articles


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