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Modulation mechanisms of voltage-gated calcium channels

Title
Modulation mechanisms of voltage-gated calcium channels
Authors
Park, Cheon GyuSuh, Byung Chang
DGIST Authors
Park, Cheon Gyu; Suh, Byung Chang
Issue Date
2018-04
Citation
Current Opinion in Physiology, 2, 77-83
Type
Article
Article Type
Review
ISSN
2468-8673
Abstract
Voltage-gated calcium (CaV) channels mediate diverse essential physiological functions through membrane depolarization-induced Ca2+ influx. Malfunction of CaV channels causes various pathophysiological disorders. A wide range of cellular signals, including phosphoinositides, auxiliary CaV β subunits, Ca2+/calmodulin, and phosphorylation, are crucial for finely controlling the activity of CaV channels. Various interacting proteins, such as 14-3-3 protein, densin, and stac3, are also important in regulating the surface expression of CaV channels. Here, this review provides recent advances in the regulatory mechanisms of CaV channel gating and trafficking. © 2018 Elsevier Ltd
URI
http://hdl.handle.net/20.500.11750/9240
DOI
10.1016/j.cophys.2018.01.005
Publisher
Elsevier Ltd
Related Researcher
  • Author Suh, Byung-Chang Laboratory of Brain Signal and Synapse Research
  • Research Interests Molecular mechanisms of epilepsy and sensory pain transmission; Signaling mechanism of ion channel regulation and membrane excitability; 분자전기생리; 간질 및 통증의 분자적 기전 연구
Files:
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Collection:
Department of Brain SciencesLaboratory of Brain Signal and Synapse Research1. Journal Articles


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