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Modulation mechanisms of voltage-gated calcium channels
- Title
- Modulation mechanisms of voltage-gated calcium channels
- Authors
- Park, Cheon Gyu; Suh, Byung Chang
- DGIST Authors
- Park, Cheon Gyu; Suh, Byung Chang
- Issue Date
- 2018-04
- Citation
- Current Opinion in Physiology, 2, 77-83
- Type
- Article
- Article Type
- Review
- ISSN
- 2468-8673
- Abstract
- Voltage-gated calcium (CaV) channels mediate diverse essential physiological functions through membrane depolarization-induced Ca2+ influx. Malfunction of CaV channels causes various pathophysiological disorders. A wide range of cellular signals, including phosphoinositides, auxiliary CaV β subunits, Ca2+/calmodulin, and phosphorylation, are crucial for finely controlling the activity of CaV channels. Various interacting proteins, such as 14-3-3 protein, densin, and stac3, are also important in regulating the surface expression of CaV channels. Here, this review provides recent advances in the regulatory mechanisms of CaV channel gating and trafficking. © 2018 Elsevier Ltd
- URI
- http://hdl.handle.net/20.500.11750/9240
- DOI
- 10.1016/j.cophys.2018.01.005
- Publisher
- Elsevier Ltd
- Related Researcher
-
-
Suh, Byung-Chang
Laboratory of Brain Signal and Synapse Research
-
Research Interests
Molecular mechanisms of epilepsy and sensory pain transmission; Signaling mechanism of ion channel regulation and membrane excitability; 분자전기생리; 간질 및 통증의 분자적 기전 연구
- Files:
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- Collection:
- Department of Brain SciencesLaboratory of Brain Signal and Synapse Research1. Journal Articles
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