Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ono, Yumie | - |
dc.contributor.author | Esaki, Kimiya | - |
dc.contributor.author | Takahashi, Yuta | - |
dc.contributor.author | Nakabayashi, Mikie | - |
dc.contributor.author | Ichinose, Masashi | - |
dc.contributor.author | Lee, Kijoon | - |
dc.date.accessioned | 2018-09-17T12:52:32Z | - |
dc.date.available | 2018-09-17T12:52:32Z | - |
dc.date.created | 2018-09-17 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.citation | Biomedical Optics Express, v.9, no.9, pp.4539 - 4551 | - |
dc.identifier.issn | 2156-7085 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/9291 | - |
dc.description.abstract | We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the mechanical pain threshold of the hind paw of streptozotocin-induced type I diabetic rats were continuously monitored once per week for 70 days. Significantly decreased baseline blood flow and reactive hyperemia responses were observed as early as 1 week after hyperglycemia induction. The reactive hyperemia response at 2 weeks of hyperglycemia was highly correlated with the mechanical pain threshold at 8 weeks, at which time a decreased pain threshold was statistically confirmed in hyperglycemic rats relative to controls. © 2018 Optical Society of America. | - |
dc.language | English | - |
dc.publisher | OSA - The Optical Society | - |
dc.title | Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1364/BOE.9.004539 | - |
dc.identifier.wosid | 000443313700040 | - |
dc.identifier.scopusid | 2-s2.0-85052734087 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Biomedical Optics Express | - |
dc.contributor.nonIdAuthor | Ono, Yumie | - |
dc.contributor.nonIdAuthor | Esaki, Kimiya | - |
dc.contributor.nonIdAuthor | Takahashi, Yuta | - |
dc.contributor.nonIdAuthor | Nakabayashi, Mikie | - |
dc.contributor.nonIdAuthor | Ichinose, Masashi | - |
dc.identifier.citationVolume | 9 | - |
dc.identifier.citationNumber | 9 | - |
dc.identifier.citationStartPage | 4539 | - |
dc.identifier.citationEndPage | 4551 | - |
dc.identifier.citationTitle | Biomedical Optics Express | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | POSTOCCLUSIVE REACTIVE HYPEREMIA | - |
dc.subject.keywordPlus | ENDOTHELIAL DYSFUNCTION | - |
dc.subject.keywordPlus | VASCULAR-DISEASE | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | DEEP TISSUES | - |
dc.contributor.affiliatedAuthor | Ono, Yumie | - |
dc.contributor.affiliatedAuthor | Esaki, Kimiya | - |
dc.contributor.affiliatedAuthor | Takahashi, Yuta | - |
dc.contributor.affiliatedAuthor | Nakabayashi, Mikie | - |
dc.contributor.affiliatedAuthor | Ichinose, Masashi | - |
dc.contributor.affiliatedAuthor | Lee, Kijoon | - |