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Drp1-Zip1 interaction regulates mitochondrial quality surveillance system
- Drp1-Zip1 interaction regulates mitochondrial quality surveillance system
- Cho, Hyo Min; Ryu, Jae Ryun; Jo, Youhwa; Seo, Tae Woong; Choi, Ye Na; Chung, Jee Min; Cho, Bongki; Kang, Ho Chul; Yu, Seong-Woon; Yoo, Soon Ji; Kim, Hyun; Sun, Woong
- DGIST Authors
- Cho, Bongki; Yu, Seong-Woon
- Issue Date
- Molecular Cell, 73(2), 364-376.e8
- Article Type
- Author Keywords
- mitochondrial quality surveillance; mitochondrial quality control; mitophagy; mitochondrial fission; mitochondrial membrane potential; Drp1; Zip1
- DYNAMIN-RELATED PROTEIN-1; SUPEROXIDE-PRODUCTION; CELL-DEATH; DRP1; MEMBRANE; FISSION; PERMEABILITY; MITOPHAGY; DEPOLARIZATION; DEGRADATION
- Cho et al. report that Drp1 that is the executioner for mitochondrial fission can reduce the mitochondrial membrane potential (MMP) during the mitochondrial division, and this new action helps identify bad sectors in the interconnected mitochondria. © 2018 Elsevier Inc.Mitophagy, a mitochondrial quality control process for eliminating dysfunctional mitochondria, can be induced by a response of dynamin-related protein 1 (Drp1) to a reduction in mitochondrial membrane potential (MMP) and mitochondrial division. However, the coordination between MMP and mitochondrial division for selecting the damaged portion of the mitochondrial network is less understood. Here, we found that MMP is reduced focally at a fission site by the Drp1 recruitment, which is initiated by the interaction of Drp1 with mitochondrial zinc transporter Zip1 and Zn 2+ entry through the Zip1-MCU complex. After division, healthy mitochondria restore MMP levels and participate in the fusion-fission cycle again, but mitochondria that fail to restore MMP undergo mitophagy. Thus, interfering with the interaction between Drp1 and Zip1 blocks the reduction of MMP and the subsequent mitophagic selection of damaged mitochondria. These results suggest that Drp1-dependent fission provides selective pressure for eliminating “bad sectors” in the mitochondrial network, serving as a mitochondrial quality surveillance system. © 2018 Elsevier Inc.
- Cell Press
- Related Researcher
Laboratory of Neuronal Cell Death
Molecular mechanisms of neuronal cell death and neurodegeneration
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- Division of Biotechnology1. Journal Articles
Department of Brain and Cognitive SciencesLaboratory of Neuronal Cell Death1. Journal Articles
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