Cited 4 time in webofscience Cited 5 time in scopus

Drp1-Zip1 interaction regulates mitochondrial quality surveillance system

Title
Drp1-Zip1 interaction regulates mitochondrial quality surveillance system
Authors
Cho, Hyo MinRyu, Jae RyunJo, YouhwaSeo, Tae WoongChoi, Ye NaChung, Jee MinCho, BongkiKang, Ho ChulYu, Seong-WoonYoo, Soon JiKim, HyunSun, Woong
DGIST Authors
Cho, Bongki; Yu, Seong-Woon
Issue Date
2019-01
Citation
Molecular Cell, 73(2), 364-376.e8
Type
Article
Article Type
Article
Author Keywords
mitochondrial quality surveillancemitochondrial quality controlmitophagymitochondrial fissionmitochondrial membrane potentialDrp1Zip1
Keywords
DYNAMIN-RELATED PROTEIN-1SUPEROXIDE-PRODUCTIONCELL-DEATHDRP1MEMBRANEFISSIONPERMEABILITYMITOPHAGYDEPOLARIZATIONDEGRADATION
ISSN
1097-2765
Abstract
Cho et al. report that Drp1 that is the executioner for mitochondrial fission can reduce the mitochondrial membrane potential (MMP) during the mitochondrial division, and this new action helps identify bad sectors in the interconnected mitochondria. © 2018 Elsevier Inc.Mitophagy, a mitochondrial quality control process for eliminating dysfunctional mitochondria, can be induced by a response of dynamin-related protein 1 (Drp1) to a reduction in mitochondrial membrane potential (MMP) and mitochondrial division. However, the coordination between MMP and mitochondrial division for selecting the damaged portion of the mitochondrial network is less understood. Here, we found that MMP is reduced focally at a fission site by the Drp1 recruitment, which is initiated by the interaction of Drp1 with mitochondrial zinc transporter Zip1 and Zn 2+ entry through the Zip1-MCU complex. After division, healthy mitochondria restore MMP levels and participate in the fusion-fission cycle again, but mitochondria that fail to restore MMP undergo mitophagy. Thus, interfering with the interaction between Drp1 and Zip1 blocks the reduction of MMP and the subsequent mitophagic selection of damaged mitochondria. These results suggest that Drp1-dependent fission provides selective pressure for eliminating “bad sectors” in the mitochondrial network, serving as a mitochondrial quality surveillance system. © 2018 Elsevier Inc.
URI
http://hdl.handle.net/20.500.11750/9533
DOI
10.1016/j.molcel.2018.11.009
Publisher
Cell Press
Related Researcher
  • Author Yu, Seong-Woon Laboratory of Neuronal Cell Death
  • Research Interests Molecular mechanisms of neuronal cell death and neurodegeneration
Files:
There are no files associated with this item.
Collection:
Division of Biotechnology1. Journal Articles
Department of Brain and Cognitive SciencesLaboratory of Neuronal Cell Death1. Journal Articles


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